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Language: en
probably about three months ago I
started getting really itchy and then
just like in like my chest would itch
like crazy my back would it's like crazy
I'm like what is going on because I'm
really religious on my diet I don't
cheat in my diet but a couple times a
year like I'm really hardcore about it
and then it started with like a little
spot on my neck and then it was like I
had to wear like long sleeve everything
I was just one big rash it was it was
insane and I've never had anything like
that in my life
and so I was like this I know this is
something I'm eating just like in my gut
I can feel that that's true but I
haven't changed my diet I was like what
could this be and before I give you the
punchline of what I think it is
what when you hear stuff like that where
do you go
well you're the best way to think about
your skin is your the lining of your gut
is actually your skin turned inside out
that's fascinating and so you have from
your mouth all the way down to your anus
a tube that's got the surface area of a
tennis court and everything that you
swallow is actually outside of you
as it's moving through the inside skin
has to do the same functions as the
outside skin and that is kind of keep
things away from us but it's got a fatal
flaw it not only has to keep things out
but it has to let things in like the
proteins and the fats and the sugars
that we eat so that's where the Mischief
can happen but when I see someone with
an external skin problem it's always a
reflection of what's actually happening
in the gut what is that process what
does it look like how can people that
are watching this now if they're
struggling from something how do they
begin that process of repair
so you know I think the first thing you
do is get major lectin-containing Foods
out of your diet you won't like me for a
couple weeks but most people even within
a couple weeks begin to notice a
difference now what are those there are
foods that we actually evolutionary were
not designed to eat
beans are so lethal raw that there's
very good published studies in humans
that they can cause massive bloody
diarrhea and there's some pretty good
studies in monkeys rhesus monkeys and
red velvet monkeys that they can
actually cause heart disease and even
kidney damage from the lectin content
what's fascinating from a human
evolution standpoint is that humans up
until the dawn of Agriculture were
actually very tall creatures most humans
were about six feet tall and our brain
size was about 15 percent bigger than it
is today
and when if you look chronologically by
8 000 years 2000 years into grain and
bean eating we actually shrunk about a
foot and our brain size has never
recovered from 10 000 years ago so these
are
anti-nutrients grains and beans that's
number one
number two two thousand years ago
northern European cows suffered a
genetic mutation spontaneous mutation
where they stopped making the normal
protein in milk casein A2 and began
making casein A1
now casein A1 has a lectin-like protein
that is converted into a compound called
beta caseiomorphine which can cause a
direct immunologic attack on the beta
cell of the pancreas the insulin
producing cell in the pancreas and
there's some pretty good evidence and
it's accumulating every every year that
one of the causes of type 1 diabetes or
juvenile diabetes is casein A1 milk and
it actually correlates very well
in countries that have casein A1 cows
they have much higher incidence of type
1 diabetes than countries that have
casein A2 cows
cheeses for instance are safe from
France Italy and Switzerland
sheep goats and water buffalo are all
casein A2 and what is it about that
that's so problematic it actually makes
a it's a lectin-like compound that
stimulates an immune response so just as
I would get from the beans or whatever
you'll get the same thing okay so it's a
it's a very new addition to our diet now
the newest addition to our diet is some
of our most precious foods are American
North American or South American foods
for instance in the nightshade family
potatoes eggplant peppers tomatoes and
Goji berries so the the nitrates the
peel and the and the seeds have the
lectins and Native American Indians in
the southwest always
peel and de-seed their peppers they Char
their peppers they deseed them and then
they either grind it into chili or eat
them that way but they always do that
the
Italians always peel and de-seed their
Tomatoes before they make sauce and is
this like a cultural intuition kind of
thing where they where do I what I like
to do is I go around the world studying
cultures and figuring out why did they
do this how did they detoxify lectins
for instance rice was invented 8 000
years ago four billion people use rice
as their staple yet four billion people
take the hall off of rice and eat it
white and surely there can't be four
billion dumb people who don't know any
better that white rice is bad for them
and brown rice is good for them in fact
they've been taking the hall off of rice
for 8 000 years
same way believe it or not up until
William William and Harvey Kellogg in
the early 1900s did the idea that whole
grains were good for us and if you look
back 50 years
and when the whole grain goodness really
caught on you'll notice that a lot of
our current health issues including this
epidemic of autoimmune disease didn't
occur this epidemic of dementia didn't
occur and so whole grains are one of
those wonderful myths that got
perpetrated by a few individuals the
other individual that perpetrated this
English surgeon by the name of Dr
Burkett
and Dr Burkett did some missionary work
in Africa in the middle of the sen of
the last century and he is a colon
surgeon a guy who would operate on colon
Cancers and he went down there to do
some work and nobody had colon cancer he
actually went around and watched and
looked at the bowel movements of these
Africans who were eating huge amounts of
tubers things like yams for instance or
celerac root or jicama and their bowel
movements were huge and he goes wow you
know look at all they're eating all this
fibrous stuff and it must be that the
fiber in their diet is keeping them from
having colon cancer
so he came back to England and he
espoused the the fiber theory of
preventing cancer
now the problem is in England they
didn't have a lot of these sorts of
tuberous foods but they had tons of
what's called insoluble fiber in the
form of wheat and rye and barley and
even oats so he didn't know the
difference between insoluble fiber and
soluble fiber and so he said we should
all be eating fiber and so that's
actually where that whole idea that the
hall was actually good for you now the
ironic thing is he actually died of
colon cancer
that is very ironic very ironic there's
a saying among surgeons that we always
die from the disease we treat so
well then so that there's so many
interesting points in there talk to me
about how animal Meats end up because
you don't eat hardly any
um how how does lectin find its way into
animal meat we raise animals with
antibiotics and this was discovered by
by accident years ago when they were
thinking that antibiotics might be
needed for crowded conditions of you
know Stockyard animals but the
researcher found out that by giving
antibiotics to these animals they grew
faster and got fatter much quicker than
the animals who didn't get the
antibiotics so it was approved by the
Department of Agriculture and the FDA to
give antibiotics to animals for the
purpose of growth
those what we didn't know is that those
residual antibiotics are incorporated
into the meat the beef the chicken the
pork you name it and so we actually
every time we ingest Factory raised
meats or even farm-raised fish ingest
micro doses of antibiotics
micro doses of antibiotics are
incredibly effective at killing off your
microbiome
so in the last 40 years we've had this
you know
incredible you know the the worst storm
that could possibly happen for our
microbiome and for our leaky gut
so then our lectins their elect and like
substances in the meat but is there
actually lectin itself great question
there was just paper published from Ohio
State a few weeks ago that shows that
lectins and soybeans can be found in the
meat of animals that you feed them to
now I used to think that this was kind
of fanciful in the alternative medicine
world you know you are what you eat but
you are with the thing you're eating ate
and as I started seeing more and more
autoimmune patients
we had case reports
of particularly there's a woman
psychologist in La that I talk about in
the book who had horrible lupus was on
Two drugs and we got her off of all her
drugs by following this program
and her her lupus cleared she had rashes
and
um she she came back to see me and she
said you know everything's great but
I've got this eczema this little rash on
my upper eyelids and so we're going
through the list I said well something's
getting into you and we get to
pasture-raised chicken and I said now
you're you're eating past your raised
chicken cheese oh yeah I eat organic
free-range chicken all the time it's my
go-to food I said
free-range chicken and she said yeah
yeah you know organic free range I said
well the federal government in 2007
passed a law that says you can keep
000 chickens in a warehouse
feed them organic corn and soybeans and
not let them out of the warehouse except
open a door for five minutes every 24
hours and the chicken has the potential
to go outside and that is the current
government definition of organic
free-range chicken wow so she was eating
the lectins of soybeans and corn in the
chicken that she was eating I trained in
London England for children's heart
surgery and my kids were four and six
years old
and they missed Kentucky Fried Chicken
terribly in a Kentucky Fried Chicken
opened in London now in those days there
was so much fish available in England
that the chickens were fed ground up
fish meal and the the chicken breasts
were actually translucent like fish
and uh so you know we go to Kentucky
Fried Chicken they both grab a drumstick
and they bite it under the drumstick and
my four-year-old goes oh oh you tricked
us this is fish ooh this isn't chicken
and I'm going oh no no no no look you
know drumstick you know Colonel Sanders
that's chicken no it's fish
well she was right
it wasn't a chicken it was
a chicken with feathers that was
actually a fish
so we have to realize that our chickens
are no longer chickens they're an ear of
corn with feathers Americans are 70
percent carbon atoms from corn a
substance that we were never exposed to
until 500 years ago Europeans are five
percent corn in fact France in 1900
banned corn is unfit for human
consumption wow
so what I want people to do is is eat
and party like it's 9
999 years ago before we started all this
mess
and when we do that with people and
teach them how to do it
it's amazing what happens to them well
let's talk about that because if I had
only heard some headlines about you I
would have thought oh red meat I'll get
after it because I eat a ton of red meat
and think I'm doing healthy things so
you don't eat a lot of meat why not so
we found that there was a molecule sugar
molecule
on the wall of pig blood vessels that's
totally different from the sugar
molecule that's in ours but it differs
by only one actually atom and it's new
it's called new 5gc in pigs cows and
lambs and we carry what's called new 5ac
and I have nothing against red meat but
if you look statistically the red meat
eaters do have significantly more
coronary artery disease and
significantly more cancer now why cancer
well it turns out that cancers tumors in
humans use new 5 GC to Shield themselves
from detection by the immune system the
problem is we don't manufacture new 5gc
nor can a cancer cell which means they
acquired it from external sources namely
beef lamb and pork now fish doesn't
carry it they have the same molecule
that we do and chicken have the same
molecule that we do
so I urge people if they're going to eat
animal protein and I I do to use wild
shellfish or wild fish as their main
source of animal protein do I eat meat
yeah I mean do I eat beef I do but I get
grass fed and grass-finished beef and I
use it as As a treat not as a Mainstay
of my diet
and then what's your take on eggs
the yolk of the egg may be the most
beneficial food that has ever been
invented and as long as the chickens are
fed what they're designed to eat when I
actually ask people to mainly throw the
whites away so we'll do a four egg
omelet but four of them are yolks and
just use one white and what is it in the
whites or about the whites that make
them problematic okay it's animal
protein and let's look at another reason
not to eat animal protein sadly
so animal protein
there we there's a sensor in all of our
cells called mtor and it senses energy
availability in its senses sugar
availability but it senses certain amino
acid availability so if you avoid or
lessen your amount of animal protein
your mtor will fall now we have no way
of measuring clinically mtor but we can
use a surrogate for that which is
insulin-like growth factor igf-1
and in my super old people and I study a
lot of super olds 95 and above
they all have extremely low insulin-like
growth factors and why why is that a
number you want to get down because
super old people always run low
insulin-like growth factors they always
do and in my upcoming book the longevity
Paradox if you look at societies of the
blue zones the longest living people on
earth
the common factor that they all have in
their diet they have very diverse diets
there's no Universal diet that these
people follow and I was a professor at
one of the blue zones well Melinda for
most of my life
the thing that separates or unites all
of those various diets is they eat very
little animal protein
and one of the things we notice about
super old people is they run low body
temperatures they're running 96 degrees
whereas you and I are running 98.6 and
they become incredibly efficient
creatures my mentor Dr Morrow always
said that you only have so many
heartbeats and when you use those up
that's the end and he's actually right
in a lot of ways but the corollary to
that is let's suppose Your Design is
that you only get so many calories in
your lifetime
and you can use them quickly or you can
spread them out and that's why that's
why fasting
is so useful and intermittent fasting is
so useful because it's actually an easy
way
just to reduce your calorie intake and
it's you know once you learn how to do
it it's it's an easy way to make this
system work how do you pull it off so
I'm a huge proponent of intermittent
fasting and fasting in general how do
you do how do you make it an easy
process
so I started uh 11 years ago at January
1st to June 1st
but during the week I would eat all my
calories in a two hour window from six
to eight o'clock at night so the 22 out
of the 24 hours every day five days a
week I was fasting 22 hours now why six
to eight o'clock at night because that's
when my wife and I were at home and
um now this is as you know for a
professional driver on a closed course
what most people who try to do this
don't realize about 80 percent of us in
America
are insulin resistant we have much too
much insulin production
and I won't bore you or the listeners
but most people can't do prolonged
fasting for even more than a few hours
because they can't access the fat that
they've stored
and they crash and it's often called the
Atkins flu or the low carb flu where
they have to be able to transition over
to using ketones as a fuel now you can
get there fairly quickly and we have
tips in the book on how to do that you
actually have to use exogenous ketones
for a while things like MCT oil things
like coconut oil even red palm oil
there's a little bit of exogenous
ketones in butter it's called butyric
acid yeah it's um intermittent fasting
is really really powerful for
alleviating brain fog for changing your
relationship to hunger is how I always
think of it as just fundamentally
different and then getting your
Machinery used to actually accessing
your body fat and all that we're
designed to use up fat we just have to
you know use the tricks to get to that
fat for most people who are overweight
or obese what's so frustrating for them
is they try things like intermittent
fasting and they're pretty miserable
they get headaches and they're very
hungry their brain is going hey you know
what what's the deal you've cut me off
it's water water everywhere and not a
drop to drink and we see so many
overweight and obese people and I was 70
pounds overweight I was obese running 30
miles a week and going to the gym one
hour a day and going why how come I'm
such a fekka
I couldn't get to my fat stores because
I had an elevated insulin level when I
first you know got my insulin album
wow
um
what's that now I have a very low
insulin no that stuff is fascinating in
terms of the complexities of really
breaking through and figuring out for
you what do you have to do to lose fat
keep it off and yeah it's a very complex
thing and to that end not necessarily my
question is not really about fat loss
but
um given what we've been talking about
lectins and autoimmune and all of those
joints aches pains all the things that
come along with it psoriasis all of that
what should people be eating so we we've
got a rough sense of what we should be
avoiding but what should we be actively
pursuing okay so uh the only purpose of
food is to get olive oil into your mouth
there are three long-lived Societies in
the blue zones that use a liter of olive
oil per week
that's about 12 to 14 tablespoons a day
can I use it to saute you can use it to
saute believe it or not there's a
wonderful paper from the NIH showing
that olive oil does not break down into
harmful compounds that's amazing but
bring olive oil to the table so if
you're going to have a steak please pour
it on your meat as they do in Italy they
always bring a bottle of olive oil so
you can have steak Florentina and just
drench it with olive oil the steak is
there to get olive oil into your mouth
broccoli is there to get olive oil into
your mouth a salad is there to get olive
oil into your mouth so
there are wonderful cruciferous
vegetables you can have all the bok choy
broccoli cauliflower have cauliflower
pizzas there's a great recipe in my
cookbook for cauliflower pizza uh can I
have Japanese sweet potatoes yes please
oh they're so good yeah but the purpose
of the sweet potato is to get olive oil
into your mouth yes which works for me
just fine if I can saute or use an air
fryer yeah have you done yes everything
oh my God they're like french fries they
sure are so yeah so those are great for
you things like Yucca or Yucca make
phenomenal french fries but parboil them
first and then put them in the airfryer
also any tuber so like celerac root is
fantastic jicama so get some guacamole
believe it or not true guacamole does
not have tomatoes in it that's an
American whatever
and get yourself some hika mistakes
Trader Joe's has them lots of plain old
grocery stores have them use that as
your dipping chip other thing I like
people to get is
vegetables in The Chicory family the
more chicory you can get in your life
Radicchio the kind of Italian red
lettuce is pure inulin and your gut bugs
will love I love it for you I want to
believe that we can sort of age in
Reverse so we can get stronger better
looking more robust as we age but that
is not conventional wisdom but you
debunk it right off the bat yeah hit us
with it we want to be a Benjamin Button
so you know we want to actually de-age
and I really think it's possible in fact
when people look at my pictures really
at the height of my surgical career in
the mid 90s and then compare those
pictures to me now there's actually no
doubt that I'm actually a younger man
than I was almost 30 years ago better
skin like what are we judging that by
better skin better yeah better texture
my skin one of the things I talk about
in the book extensively is your your
skin is actually a mirror of the lining
of your gut your the lining of your gut
which is the surface of a tennis court
is actually your skin turned inside out
what is it that makes you think that the
gut is so influential in aging
specifically because people think of
like I'm going to get arthritis it's
wear and tear it just is what it is I've
used my joints so much that you know
they're they're going to be tapped out
like it it actually does make intuitive
sense and so what you talk about in the
book is really sort of kicks people into
a new way of thinking about it so why is
the gut so tied to what we think of as
actual aging so uh
here's the deal uh there's a there's a
wonderful animal model for aging that
involves a little worm called sea
elegans uh it only lives about three
weeks so you can do an intervention in
it and kind of instantly know what's
going to happen and so in this model the
influence of the bacteria the microbiome
and the wall of this little creatures
got the the lining of the gut is only
one cell thick and they're all kind of
held together with what are called tight
junctions a locked arm and arm like a
game we played Red Rover Red Rover that
kids don't play anymore
so the bacteria are foreign if you will
and there is an interaction with the
bacteria in the gut
and what this model shows is that as
those bacteria begin to break holes in
the gut break down the gut then you can
show that that is when aging starts and
the more the wall breaks down the faster
you age the truth is hitting your career
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free by clicking the link in today's
description all right my friend back to
today's episode so let's uh break down
what is aging exactly like what are we
so I think most people would sort of go
to
Mobility
Aesthetics and maybe accumulation of
disease like how would you define aging
specifically so aging to me is the
either quick or slow breakdown of the
gut wall how do we know that well we can
take a look at
105 year old people around the world
you can look at their microbiome the
collection of bugs in their gut
they will have a very diverse set of
bugs they'll have you know it takes a
village this really incredible tropical
rainforest
and those microbiome that collection
will be identical to a healthy 30 year
old
so what that says is that these healthy
105 year olds are healthy
because they have the microbiome of a 30
year old and it's this microbiome that
is not attacking the wall of their gut
that's actually existing with the wall
of God and we I talk a lot about this
crazy bug that may be the key to
longevity and it's got a great name
Ecker monsia mucinophilia say that three
times say that once yeah
so this bug lives in a mucous layer that
aligns our gut and if we're lucky and
the way we're designed we're supposed to
have a layer of mucus lining our gut
before we get to the cells and that
mucus is there to number one trap my
favorite subject lectins which are plant
proteins that are looking for sugar
molecules
and number two it's to protect the wall
of the gut
from bacteria that might do us harm
so ackermansia lives in the mucous layer
and it actually eats the mucus
now here's the best part the more mucus
it eats the more our gut cells produce
mucus and it actually increases the
mucous layer
and the book is actually lots of tricks
on how to make this guy happy because
the thicker our mucus the younger we are
in fact fun fact
metformin we now know works by
increasing the amount of acromancia in
our gut not by some magical mystical
thing happening in our body in fact
interestingly about 25 of people when
they start metformin get diarrhea and
it's actually because the gut microbiome
changes dramatically on on Metformin and
one of the reasons is that necromancia
becomes predominant
interesting so at a cellular level
what's happening with metformin
something that simply triggers the body
to produce mucus in general is it is it
changing the microbiome you called it a
rainforest earlier is it changing the
makeup of that rainforest or is it just
actually compelling the body to create
more mucus no I think it's actually
changing it's selecting out for
acromancia now how does it do that
because there's actually kind of a shag
carpeting on the lining of our gut so
plants have Roots going into the ground
we know the roots actually absorb
nutrients because of the soil microbiome
all the bacteria all the fungi actually
deliver the nutrients into the roots of
the plant
well we have a root system and that root
system is this shag carpet that makes
the line camera got a tennis court okay
so the reason it's so big in surface
area is it loops around itself with
little one cell thick protrusions called
microvilli okay okay these are our Roots
they literally are Our Roots at the
bottom of these microvilli or what are
called Crips
at the bottom of The Cribs there is a
pocket of
bacteria that are essential
and they're down there in storage in
fact fun fact we now know the appendix
is not useless it's one of these storage
systems to repopulate our gut if you
lose your appendix you're screwed for
that part of your story system but down
at the bottom of these Crypts are these
little collection of bacteria and at the
bottom of these Crypts are our stem
cells that actually repopulate these
microvilla
so what happens is if we damage this
lining and boy do we damage the steining
swallow and ibuprofen it's like
swallowing a hand grenade
take some food with Roundup in it
Roundup will destroy the lining of your
gut it's really good stuff Roundup in
itself will destroy your bacterial
population all right really fast because
I think this is important and for some
reason
um even though I've had you on the show
before I really read the book like the
way that you've started talking about
some of the places that you're going to
find also known as glyphosate in the
system that basically they're part of
why they're doing it was originally
created as a or patented as a antibiotic
which that was already shocking and then
you said they use it as a way to be able
to dry the crops out so they can Harvest
them on a specific day very good but
then you said they don't no one wipes
them off and so it ends up in Cheerios
and other things and I was like what
like I thought if I was washing my
vegetables I was going to be fine so
this was a little bit startling to me
yeah you know you know a little off
subject but they've looked up recently a
study of 35 of oat products in the
United States and all of them had
glyphosate in them some of them at very
high levels some of our breakfast
cereals most of our granolas most of our
granola bars
most California wines including a couple
of organic wines have glyphosate in them
because the the fields are sprayed the
weeds are sprayed with glyphosate
between the vines to kill the weeds
research at MIT has shown that not only
does glyphosate
kill bacteria because bacteria use the
same reproductive pathway that plants
use it's the shikamate pathway humans
don't use the sugar mate pathway and so
Monsanto when they invented it said hey
this kills plants but don't worry it
doesn't kill humans because we don't use
the same pathway for life and everybody
said oh that's great you know this is a
miracle what they didn't tell anybody is
the bacteria use the same pathway and
again they patent this as an antibiotic
they didn't patent it as an herbicide
what else are people doing that is
um breaking the bonds or killing the
bacteria the antibiotics in their food
or that they're taking themselves in
fact studied just out this morning
shows that women who take antibiotics
just you know because a urinary tract
infection
sore throat
have a much higher incidence of heart
disease than women who don't that's
scary now this gets into something in
your book that was super freaky uh I've
never heard somebody say and I'm not
saying that no one's ever said it I had
never heard anybody say until reading
this that heart disease is an autoimmune
disease yeah so because it ties into
this point
how is heart disease autoimmune disease
how does that start in the gut what does
that whole Chain Reaction okay so
um Michael DeBakey one of the
Premier Originators of heart surgery
from Houston Texas would always say that
cholesterol has nothing to do with
causing heart disease that it's an
innocent bystander that literally gets
sucked into
inflammation at the wall of the blood
vessel and I use the example of let's
say you know I'm an alien and I'm you
know circling above LA and I report back
that I'm pretty sure that ambulances
cause car accidents because every time I
see a car accident there's an ambulance
there and the ambulance must have caused
it well you know causation Association
is not causation so the fact that we see
cholesterol in deposits and I see it you
know every day in the operating room
there's cholesterol in these plaques
doesn't mean that the cholesterol cause
the plaque so I learned this as an
infant heart transplant surgeon what we
found was we thought naively that if we
got these hearts in as a newborn that
the immune system of the newborn would
not be mature enough and would say oh
yeah that you know that's my heart I
don't know any better and it wouldn't
attack it
well we're partially right but as the
years went and we studied these kids
they started to get coronary artery
disease their blood vessels got
thicker and thicker that is super
interesting and we're going well what
the heck so did they look just like
somebody who we would have associated
with too much cholesterol in their diet
it looks just like diabetic coronary
arteries interesting just like and so
when you actually look at the blood
vessels
the kids the lining of the blood vessel
is from the donor from a foreigner the
blood going through is from the kid
and the blood says wait a minute these
are foreign cells and they're I'm going
to attack them just think of a splinter
under your finger you you know it's all
red so that's inflammation and what was
happening was then cholesterol was
basically coming as a patch an ambulance
and it was getting caught up in this
inflammation so then we look at these
adults who obviously don't have heart
transplants and you go well that's funny
this looks just like a kid who has you
know somebody else's heart and there's a
attack on the blood vessels that looks
identical as if it was a foreign object
so that got me going you know this is an
immunologic reaction and in just a few
weeks and I can't tell you the paper
because it's embargo and I'm giving a
paper at the American Heart Association
vascular biology meeting
that makes a pretty good case that
lectins which are a foreign protein that
can stick to sugar molecules on the
surface of blood vessels uh are the
cause of atherosclerosis in humans and
that removing lectins reduces the
markers for that all right really fast
then we talked about this in our first
issue or first episode but I think it
Bears repeating like what's the real
quick uh breakdown of lectins and the
the rhetoric you started using around
kidney beans I found really interesting
yeah so lectins are the plant defense
system one of the plant defense system
I'm pretty doggone a good one plants do
not want to be eaten they don't want
their babies eaten and they have
evolutionary pressures to keep being
eaten and have their babies not being
eaten and lectins are one of the ways to
do this they are sticky proteins that
look for specific sugar molecules to
stick to and that incites an
inflammatory response wherever they
stick we talked about joints wearing out
joints do not come with a sell-by date
or use by date there is no evidence that
the wear and tear theory has anything to
do with a human body we can constantly
rebuild cartilage but like I talk about
in the book cartilage is broken down by
certain cells and rebuilt by other cells
and we can if you had arthritis we could
stick a scope in you suck out some of
the fluid we could actually find
bacterial particles in your joint fluid
wow okay so really fast because I know
where you're going with that but now now
connect those dots how do those parts
get into the joint lectins broke down
the wall of your gut and on the other
side of your gut is 65 of all your white
blood cells 65 of your immune system is
lining your gut
what are they doing there because the
gut is where the outside world gets
through and they're there to sound the
high alert and attack them when they get
through
one of the reasons we store fat in our
gut we're on the reasons we have a beer
belly or a wheat belly is we are
actually putting fat down where the
action is it's to supply the troops
that's why we put it there in fact when
I operate on people with Advanced
coronary disease there is a layer of fat
that is on the surface of the blood
vessels and there is a perfect
correlation to the amount of
inflammation and disease in the blood
vessel with the amount of fat
surrounding the blood vessel whoa this
is in humans published studies so we
don't this is not conjecture and I
reference this in all my books
wow okay so here's my understanding of
fat 45 seconds ago which may now be
changing
um one that fat is essentially an organ
but I think of it as an energy storage
unit that we can certainly access and
and break down and turn it into energy
that the body is very efficient at
Burning ketones certainly the brain
um so what exactly is it doing at these
areas of inflammation so maybe 15 years
ago we thought the fat was actually
causing the inflammation because
wherever we found fat there were lots of
white blood cells
what I think recent information is
proven is that the fat is not the evil
guy that we thought it was that the fat
is there because of the inflammation and
the inflammation is there because you
have a leak in your gut you have a leaky
gut
yes your white blood cells require huge
amounts of energy to do their job okay
and so you it just it's just like any
army you got to have a supply line you
have to have food for the troops all
right now let me ask a really difficult
question I have no idea if this even
makes sense but it makes sense to my
Layman's mind
so many people have gotten to a
metabolic point of dysfunction so
extreme that they really never access
their fat stores true so if they're
existing in that state and they have
metabolic syndrome and the body's like
yo here's the fat take it I we have
inflammation get ready white blood cells
you can have all the energy that you
could ever use but the body doesn't know
how to click over into that mechanism
because insulin levels are elevated is
the fat getting there and the white
blood cells are unable to use it or
that's a whole different thing and
they're still able to use it that's part
of the problem it's part of the problem
you know let me use an example I used to
use with my patients
the the flu virus so the virus has a has
a barcode on it that our immune cells or
scan literally and say oh you know
that's a nasty virus that's the flu
virus we know this guy we need to get
ready to attack this and we need to get
all of our immune system up and running
and we need to make sure the immune
system has enough power to do this so
what do we do we actually make you me
hurt
hurt to move because if we move the
muscles are going to take all the energy
if you lay down then all the energy is
available for this battle to go after
this virus our immune system literally
reads barcodes to tell whether somebody
is a friend or a foe and lectins have
fascinating barcodes that
mimic other proteins in our body and
when this immune system is ramped up the
immune system goes around the body and
looks for proteins that are lectins and
let's say they come to a thyroid
and they go oh my gosh you know this
poor woman's thyroid is full of what
appear to be lectins they're not quite
the same but it's close enough and we
should you know shoot to kill and we'll
ask questions later okay so I'm gonna
I'm gonna walk through the process that
we've just discussed because wow for me
anyway and for anybody listening that's
like me once I can picture it once I can
understand it then it's like I can begin
to manipulate it and predict what I
should do and not do
okay so you eat something it could be
lectins which you'll find in the skin
and seeds of nightshade vegetables is
one example or peanuts or peanuts uh so
you eat these things they like a
glyphosate like
um ibuprofen apparently they will go in
and they'll disrupt my microbiome they
break down the single the bonds between
the Single Cell lining of my gut that
allows either entire elements of
proteins in the case of lectins or
pieces of bacteria I'm assuming dying
pieces dead pieces there's a broken arm
bacteria it turns out when
bacteria divide and they do all the time
I mean there's trillions and trillions
and trillions of them you make about
anywhere from a half a pound to a pound
of dead cell wall bacterias every day
and so those pieces are normally
excreted with your poop
most of your poop is actually bacteria
that's so weird that's what it is so
anyhow our immune system is so afraid of
bacteria they're supposed to stay on
their side of the wall
that if they see the signature of that
bacterial cell wall it doesn't know that
it's not a whole bacteria it doesn't
know that it's dead
so we can take in human volunteers
LPS's dead bacteria inject them into
your bloodstream and you will go into
septic shock whoa as if we put living
bacteria in you
whoa because what's actually happening
is my immune system is going crazy
exactly the immune system doesn't know
any better and so holy cow you know
there's there's thousands and millions
of bacteria all of a sudden in us and
you know we got to do something and they
just start attacking ah like crazy
monkeys going nuts yeah exactly and so
those particles whether they're the
lectins which by the way on lectins
really fast the whole notion of thinking
about plants not as these inert things
which until starting to read you I
always did I just thought appliances is
completely inert when you talk about
them as being sort of the world's most
sophisticated chemical warfarist that's
where it's like whoa then you begin to
realize maybe what's really going on
okay so these lectins or particles of
bacteria get into the bloodstream immune
system scans it maybe they've ended up
in the thyroid maybe elsewhere and it
just [ __ ] goes nuts starts attacking
you get inflammation which has a whole
host of knock-on effects from could be
um cholesterol trying to patch could be
the fat wrapping around the blood
vessels or the arteries or whatever the
case may be and you know we're we're now
most of us are now convinced that
Alzheimer's and Parkinson's and dementia
is
neuroinflammation okay and what's and
what people are picking up on because
they're all going to talk about the beta
amyloid plaques and you've talked about
how some of the companies targeting that
may actually be accelerating your onset
of dementia which is really terrifying
really bad um is that this is again the
alien blaming the ambulance for car
accidents yeah so most amyloid is
actually produced by bacteria in the gut
and Dale bredesen keeps saying he says
it's not the amyloid in the brain that
we should be looking at and no wonder 40
billion dollars of investment in
anti-amyloid drugs has been a total and
useless failure 40 billion dollars he
says because amyloid is produced in the
gut by bacteria and we know certain
bacteria that make it and certain that
don't and why would we give the amyloid
producing bacteria what they want to eat
which is simple sugars and saturated
fats the Western diet
plus the amyloid can't get out of the
gut unless your gut is leaky it's too
big a protein to be absorbed so Dale and
I for years have been saying Hey guys
you're looking at the wrong spot to go
after Alzheimer's so really fast let me
ask are you saying the beta amyloid
plaques are not actually create it in
the brain and that they would never make
their way to the brain you won't make
them unless they get to the brain and
then stimulate more production
that's so weird why would the brain have
the ability to produce something in the
brain that would never be turned on
unless it started from a problem in the
gut that seems way counterintuitive it's
basically so we now we now know we have
we have a leaky brain and there's
meaning things are crossing the
blood-bearing barrier they should not it
would have never done it and there's
actually a beautiful new paper that
probably explains why
cholesterol and amyloid and dementia
actually
um coexist in people with the Apple E4
gene they quote Alzheimer's Gene I got
interested in apple E4 which 30 percent
of people carry as a heart surgeon
because it causes heart disease and Dale
bredesen got interested in it because it
causes dementia Alzheimer's and lo and
behold we now know there's an intimate
connection between carrying the Apple E4
Gene and how cholesterol can be
mischievous to you and your brain and
not necessarily somebody who doesn't
carry that Gene what is the Apple e Gene
what is it doing great question so it's
a it's a carrier molecule
of among other things cholesterol and if
you carry a four mutation or a double
four mutation you do statistically have
an increased risk of developing
Alzheimer's you also have an increased
risk of developing heart disease because
it's doing because it changes the way
cholesterol is transported interesting
it's more efficient it's getting more
ambulances to the scene it's actually
worse
let's suppose the Apple E4 is a Subway
and it's carrying cholesterol and it
stops at a subway saw stop and
cholesterol gets off and it goes into
the cell does its thing and the cell
says okay I've got plenty thanks a lot
you can take the rest of the cholesterol
back and take it someplace else
so it gets back on the subway and the
subway moves on
with the Apple E4 Gene what happens is
it carries the cholesterol to the cell
on the subway but when the extra
cholesterol tries to get back in the
subway doors are closed super clear all
right and that's the problem you know
this is a transport promise drop the
stuff off just fine but normally it'd be
picking up the stuff that you know isn't
needed but it so it builds up yeah so
it's kind of a double whammy
so now let's walk people through step by
step because we haven't even gotten to
mitochondria in detail yet which we'll
get there in a minute it's such an
important part of the story but so first
I want to begin to help people to
understand what it is that breaks the
Junction in their gut because that's
such a huge part of this uh
what is it that triggers the breakdown
let's start with that
well so there's you know there's three
kind of major components so first of all
and we don't need to talk about this
extensively but lectins are plants read
the plant paradox
they're plant proteins that were
designed by plants to protect themselves
and their seeds their babies from being
eaten by making their Predator ill to
pay attention number two particularly if
we're eating a typical American diet
with lots of saturated fats lots of fats
in general and lots of sugars
we in our gut have classes of bacteria
and we have 10 000 different bacteria
and I divide them into gut buddies good
bacteria and gang members
gang members love saturated fats and
simple sugars and the problem with these
gang members is that they divide and die
and pieces of these bacteria called
LPS's
lipopolysaccharides and in all my books
I call them little pieces of [ __ ]
because that's literally what they are
these guys actually hop on
fat molecules and ride through our gut
even without a leaky gut and when they
get to the other side the immune system
cannot tell the difference between a
living bacteria and a bacterial cell
wall it's so impressive that for
instance we could take you or me
and inject these LPS's into our
bloodstream and both of us would go into
septic shock as if living bacteria had
been put into us so believe it or not in
the American diet 24 hours a day
were causing leaky gut we're assaulting
our immune system with these LPS's and
it's no wonder that just from fat we all
you know are just a giant ball of
inflammation
okay so
um for my own sake it'll be interesting
to tease out some of the ideas around
fat but first I want to stay on this
point just for a second of how people
end up getting in a state where they're
prone to having that Junction break so
I'm going to make some assertations you
tell me or assertions you tell me if
these are correct assertions or not
um so one that part of the problem is a
breakdown in the actual microbiome so
the Integrity of a well-balanced
microbiome so you've probably done
something to assault that microbiome for
a long time it could be a very
non-diverse diet so some of the bugs are
just dying out and so because they're
starved to death correct and so you get
you know some dysbiosis there you've got
people just shoveling sugar in their
face that comes in a gazillion different
forms that causes all kinds of Havoc not
only in the microbiome but elsewhere and
you know we'll get into some of the
other ramifications I'm sure later and
biotics which are causing that
glyphosate which is causing that so it's
like there are so many things that are
assaulting our guts and the reason I'm
I'm prefacing all of this is because one
thing that I've had tremendous success
with in my life is high fat low carb so
I'm curious to see like it in my n of
one experience
fat of certain kinds anyway do not seem
to be problematic and of one I'm well
aware of that so you know everybody
freaking out that that is not empirical
data I understand
um but you know there's also obviously a
pretty interesting carnivore movement
so is it certain types of fat is it only
fat when you've compromised your
microbiome or is it no no fat is in and
of itself an assault upon even a healthy
microbiome so I'm I'm the guy who's
famous for saying the only purpose of
food is to get olive oil in your mouth
so I'm absolutely not anti-fab and in
all my books I have a ketogenic plant
Paradox chapter of exactly that but
having said that interestingly enough
most fats even including olive oil are
transported across the wall of our gut
using these carriers called chylomicrons
and it's the chylomicrons that these
LPS's hop onto
so interesting the chylomicron is a
metabolite of some kind no chylomicrons
are the
moving van that literally carries fat
across your gut wall fat transverses
your gut well in a totally different way
than sugars or proteins the exception to
that is medium chain triglycerides now
medium chain triglycerides MCT oil
are a saturated fat but they are a
unique saturated fat in that they're
water soluble so they transverse the gut
wall without chylomicrons number one
and they don't enter our lymphatic
system where chylomicrons go they go
directly from our gut through our portal
vein into our liver
and in the liver MCTS actually
tell the liver to make Ketone bodies so
whenever you eat MCT oil or eat MCTS in
other forms you will automatically do
not stop do not pass go do not collect
200 you will automatically make ketones
in your liver
and they'll be released so help me
understand the difference then so if if
not all fats are bad
what are the fats that are bad that are
causing this problem I didn't I didn't
get that so sadly a lot of the saturated
animal fats are some of the biggest
Mischief Makers but
the other specifically because they're
feeding the wrong bacteria they're
feeding the wrong bacteria and if you
don't have these gram-negative bacteria
in your gut in huge amounts you will not
produce
LPS's lipopolysaccharides so you could
have
a very high fat diet as long as you
don't have these gang members in your in
your life and those gang members got
there quite frankly by eating a lot of
sugar so help me then understand so
um there you said there is a time for a
carnivore diet I'm guessing and there's
a pair a pretty narrow band where you
would recommend that but what would that
narrow band be
so we we will use it uh for an
Elimination Diet where we've got someone
who is really intolerant to plant
lectins in general and we do see these
people uh they're totally intolerant to
Raw plants most of the time
um the lectins in plants can be cooked
away there are exceptions beans you
cannot cook the lectins away
wheat you cannot cook lectins away you
can't pressure cook wheat to get rid of
lectins Oats have a molecule that mimics
gluten corn has virtually identical
molecules to a gluten in fact 70 percent
of people who are sensitive of gluten
react to Corn as if it was wheat and so
many patients yeah so many patients that
I see on a gluten-free diet for celiac
disease for extreme leaky gut they're
eating corn because it's gluten free and
when we take corn away from them so many
of them resolve the problem and you know
it's like oh my gosh you know I've been
eating corn chips and corn muffins and
cornbread and I thought that was you
know gluten-free well it is but it
cross-reacts so if you if you combine a
carnivore diet
with what I recommend in the book which
is time restricted eating or compressing
your eating window
you can I want to say get away with a
carnivore diet for a period of time
there's a very famous young lady who
follows a carnivore diet who really
wants