Kind: captions
Language: en
we have a patient for whom the root
cause of his cholesterolemia
was identified as being that he golfed
too much
and how is that a medical diagnosis it
makes no sense right so here's what was
going on
Kashif Khan welcome to the show it's a
pleasure man could be here dude I'm very
excited so what is the things that
people can do on a daily basis if they
want to stop aging or even reverse it if
possible so first of all what's aging so
aging is the literal meaning is
degradation of the cells your cells
start to unravel the DNA literally
unravels on packs and the physical
manifestation of that is you know white
hair sagging skin cells are degrading so
what causes that
inflammation
lack of detoxification and poor
oxidation so these three areas are the
key factors and why cells get harmed and
they age and then outward they use start
to age
so the answer isn't here's what
everybody should do it's more that the
answer is personalized here's what you
should do and what you should do you
should do meaning I could tell somebody
that cardiovascular activity is what you
need and to somebody else that's the
reason they would Age
yeah see that's crazy so what angle we
should probably get into the genomics of
it all so what's the difference between
genetics which I think most people are
familiar with and genomics we'll start
there and then we'll get into how it
could be possible that for some people
running is the right thing and other
people
will look hagered because of doing it so
genetics so genetics was rooted in our
Healthcare model which is respond to
illness right pill for a nail you're
sick we'll come help you why did you get
sick to begin with that's functional
genomics just like there's medicine and
there's functional medicine medicine is
go break yourself and I'll fix you maybe
functional medicine is why did you get
sick what was the root and let's deal
with that so you don't get sick or we
reverse the illness and this applies to
chronic disease and to aging when it's
acute in nature broke your arm have a
terminal cancer yes run to the hospital
and get fixed all this other stuff which
is 90 of our health care budget does not
need to happen
and what we've understood is that if you
understand biology right first then
reverse engineer what genes drive those
processes it's not about
your genome says you have an 80 chance
of Alzheimer's it's why did 20 not get
it what were they doing right their
environment choices their new
nutritionist choices that that's
Healthcare studying the healthy to teach
those habits to prevent disease or you
know not to to slow down aging or be
optimal in your energy better sleep
whatever it is that you want to do
okay so now the personalized medicine I
think is the future that seems
undeniable in terms of we're all
slightly different and so assuming that
we all have the same start Point as a
mistake however it also seems to me like
they're pretty Universal factors so what
are before we drill into like what are
the things you need to understand about
your own genetic makeup what are things
at a broad level that like I would have
thought until I started researching I
would have said everybody should be
exercising right and if somebody had
said oh I run every day I'd be like word
that's amazing if somebody said I was
lifting weights every day I'd be like
word that's amazing I wouldn't have
thought that there are some people that
are going to get themselves in trouble
by running so if that isn't one of the
universal recommendations what are even
if it's a super narrow set what are the
as close to Universal as we're going to
get I would say the the thing that
stands out the most that is the least
applied is understanding environmental
health and why do I say this the first
thing we talked about was the health of
your cells right the biggest threat to
the health of our cells is the current
environment we live in our fine
environment like SO meetings in the air
or what I eat all of that so every so
how do things enter your body you
breathe them and you eat them primarily
also Through Your Skin but primarily
these two functions the way you do that
that first line of defense here to block
and prevent also in your gut some of us
do those things differently for example
me the genetic instruction to actually
defend the gut from toxins coming in in
the food that I'm eating I don't even
have that Gene
so forget about what version or what
variant or how well I don't do that
process
so you wonder why I had eczema and
psoriasis and autoimmune conditions and
because I was eating just like everybody
else
so the reality of Who We Are
genetics are 200 000 years old by the
way so when you think about our
ancestors and let's do what grandma did
you are the same of people of 200 000
years ago our genome hasn't changed so
imagine the reality of how we live that
blip in time the last you know
industrialized couple hundred years
agriculture is 10 000 years old versus
the 200 000 years of habits that we're
wired for and you wonder why chronic
disease is so prevalent that you just
expected to have cancer and
cardiovascular conditions because the
choices that even the options are not
the right options
right the environmental option of the
pesticides in your grass the the drying
agents that dry up the wheat so they can
store them that shouldn't be an option
right and also and you wonder why
everybody's so sick this is why so
that's the one thing that I would say if
you can understand environmental
exposure and threats that will take you
far okay so we can probably spend a lot
of time on this and it's probably worth
the time but I want to make sure that we
give people breadcrumbs to follow
so understanding genetics I'm going to
give it to people really simplistically
fill in any gaps that I leave out so
genetics are are a literal instruction
manual for your body oh God that's so
generic but the that entire instruction
manual is inside of every cell but only
certain parts of the instruction manual
are made are Unwound so that that cell
type can read it so the part of the
genome that has to do with the Heart Is
Made available to cells that are heart
cells the part of the genome that has to
do with the eyes made available to cells
in the eye
and part of aging is that the wrong
parts of the genome get exposed to that
cell so you get D differentiation so eye
cells start am I a skin cell am I a
brain cell my heart cell what the hell
am I and so part of all of the
environmental insults is that it's
exposing the wrong part of the
instruction manual to that cell
but there's also the complexity which
you were alluding to a minute ago
all of us have misspellings paragraphs
out of order paragraphs that are missing
or I know in your case I didn't even
know this was possible that there are
pages that are missing so there are
things your body should do that and I'm
sure this is true for all of us I just
happen to know yours because you've
talked about it there are things that
your body is supposed to be doing that
it does not have instructions for
and when you didn't know that that was
the case for you the symptoms that you
were encountering
migraines nausea I think there was
eczema like all kinds of stuff it was
all mysterious once you understood that
you were missing that page was like okay
now I know what's going on walk people
through that story as an illustration of
that point yeah so you're you're right
on right so and that's the most eloquent
description I've ever heard you know so
it's amazing that you've understood that
level essentially what we're saying is
here's your human instruction manual
here's a code that's telling yourselves
and like you said other micro you know
processes beyond the cell what to do and
each cell knows what page to read to do
its job as a liver cell or a heart cell
Etc
if you have spelling mistakes or Pages
missing or bad code
you're not going to do the job well so
our assumption is here's how the
cardiovascular system works here's how
the hormone system works we understand
those things our assumption is we're all
doing those things the same way
we're not right we all have broken code
missing code we have exponentially
beneficial code and we overdo the job
sometimes which can cause autoimmune
conditions right the same thing that is
protective can end up hurting you if you
do too much right so now all of a sudden
you can start to read that book
and you can understand that I'm missing
a page like myself right so you underst
the page you're missing so there's the
glutathione pathway which is what it's
the main drive your of your detox
process so we know when we drink alcohol
your liver helps clear the nonsense out
and you keep whatever you want to keep
in right so some of us don't do the same
in terms of how do we react to alcohol
why because that process we don't do the
same the version of that Gene it's
possible to have what's called a copy
number variation how many copies of the
gene do you have the thing that you said
you didn't know
if you don't have the gene you don't do
that job
so how are they even supposed to cope
with the alcohol or the pollution from
you know traffic or from the pesticides
you put in your lawn we have a patient
for whom the root cause of his
cholesterolemia
was identified as being that he golfed
too much
and how is that a medical diagnosis it
makes no sense right so here's what was
going on
like me he was missing certain detox
genes didn't even have them and he would
golf four days a week and he was golfing
in Canada where I'm from where the
regulations around what you're allowed
to use is a little lack because we have
a Long Winter it's over what that's to
make the golf course so pretty and
beautiful got it pesticides got it right
how do you guys diagnose him with your
playing too much golf Yeah by looking at
his genes you see a lack of detox you
ask him about so this is all in the
context of environment you ask them what
do you do he's like I don't know man I'm
so healthy all I do is Golf and i e
right golf yes tell me more exactly and
then you start to then you ask well why
would that lead to cholesterolemia why
at the age of 38 he was actually a
clinician by the way why the age of 38 a
clinician that has studied everything
that you need to study in University
cannot get his cholesterolemia under
control it was taking Lipitor number one
prescribed drug
we can determine the quality of your
Hardware your your literal arterial
walls the inner lining of your blood
vessels he had the worst possible
quality meaning instead of this
stainless steel resilient material it
was from the genetic standpoint from a
genetic standpoint okay so you could
look at his genome and go bro like if
you're not really careful you're going
to have a heart disease just just at a
gene starting there yeah that being said
he wasn't born sick right it doesn't
mean he's going to get it you have to
make the wrong choices and he did what
he did was he golfed four days a week in
Canada where there's a lot of toxins in
the grass breathing this stuff in for
four or five hours at a time without any
detox regimen as part of his daily
routine all of a sudden there's this
free-flowing toxic insult in his blood
causing the inflammation to this bad
quality Hardware that he has which is
sole prone to inflammation and that's
one of the things we said earlier is one
of the roots of Aging so what is the
body's response to when you have
inflammation here in the inner lining of
the arteries which are such an important
part of your body it will actually
deploy cholesterol as a hormone to
reduce the inflammation
when cholesterol meets toxicity it
actually hardens and it gets deposited
and you get that buildup we can actually
determine genetically how well you
transport lipids there's that HDL LDL
process you're supposed to send it to
liver some people don't do that so well
and that's another compound layer why he
would get this so fast
so we start to unpack his habits and say
you know stop the gulf or the other dial
you turn is start detoxifying take the
right supplements eat the right foods
keep the Habit okay you're going to keep
buffing then you also need to do this or
stop the thing that's causing you the
problem or hopefully a little bit of
both
yeah so this is crazy okay your own
story which I find fascinating you're in
what an auto shop what was going on
paint fumes so you guys had a marketing
company yeah yeah so that that was in
the same building with somebody kicking
off my passion was always helping
startups grow I loved it I loved that
zero to some level and then pass it on
and I did them many times for other
people right
um me and my business partner
we had a very different experience
where three four years into our office
environment like you said eczema
migraines which was probably the worst
part he used to drive me home and I
literally opened the door and vomit out
the door in the middle of the highway
and then keep going
uh psoriasis which is different than
eczema eczema is inflammation psoriasis
as autoimmune and at this point you've
no you're not making the connection
between I smell the fumes and I start
feeling bad no well I didn't even smell
the fumes right I didn't know what all I
knew was I felt horrible and you just
believe you go to the doctor which I did
and you start getting a pill and you
believe this is part of life this is
part of aging you get sick as you age
and I believe that I truly believed it
until I asked the question why
right I'm 42 now and I was 38 at the
time I said why now all of this stuff
happening at the same time I must be
doing something wrong I want to like
really Bang a Drum here for people so
modern medicine is amazing acute care is
absolutely necessary but
if you're having headaches and you just
go how do I get rid of the headache and
you never ask why do I have a headache
you will end in a dust viral so I went
through this with my wife and it was
Insanity yeah finally figuring out what
was causing the problem but until you
get to the root cause of it you're
you could be exacerbating the symptoms
you're certainly only masking them you
have not addressed the root cause and
something I've heard you say is that all
these things you think the spoke
problems if you deal with the Hub issue
all the spokes go away that's what
happened to me I've been healthy before
I tested myself for biological aging at
that time when I started to learn that
there was a different way to control my
health and at 38 I was 43 internally so
you can do an aortic stiffness test
trying to understand how much you've
aged internally I'm now 42 and my
biological age is 33. wow so you
literally went back to the reverse
biological clock is that the Horvath
clock looking at literally you can use
so yes telomere length which my aging
paused it hasn't increased it actually
so a telomere is like these caps at the
end of your DNA and it's kind of like
wear and tear you can determine how much
damage you've done to your DNA and that
gives you some indication of Aging this
is understanding your cardiovascular
health how much stress have you put your
cells under that unraveling we were
talking about you can measure it
specifically with this pulsory area
stiffness test it's very easy you do it
on your finger so when you're saying
your age went backwards you're the
elasticity of your aorta exactly
improved yeah and the best way to paint
this picture that you're talking about I
see this cube in front of us right so
imagine if I came to you and this is
just to help people understand and this
is exactly what I went through and what
actually most people are going through
if this was a fishbowl and I came and
presented you this gift of this fish
and let's call this fish sushi so
Sushi's on the ball right and I
presented sushi in toxic polluted water
you instinctively would know let's get
her out of there and put her somewhere
else right but if you left her in there
what would happen
you would expect things like eczema
things like mood and behavior banging on
the glass life is miserable eventually
cancer right maybe cardiovasculars
everything would start to go we know
that already right
if you then put her into the healthy
water
great but what do we actually do you
leave her in the water give her a pill
for the eczema a pill for the migraine
chemo for the cancer and you stay in
that environment that's why I mean that
environmental health is our biggest
threat the things that we're doing and
the things that we're amongst are not
what we're designed for we don't have
the genetic code to cope with our
reality we literally this Fishbowl is
our reality so you have to do two things
one of two things or maybe both improve
capacity take the right supplements for
you based on what you don't do well
genetically and we're not all the same
or remove yourself from this environment
and I did both right I'm healthier than
I've ever been I don't get sick anymore
I used to miss work every couple of
weeks I just I am healthier than I've
ever been and every way imaginable right
so that's exactly what would happen if
you took Sushi from here put her here
give her some time healing that is
Health right dropping pills in there
that's not Health yeah so this is the
hardest thing about health
is it's really hard to know what is
causing the problem and like even myself
I know that it's going to be environment
or something I'm eating right like it
just or sleep but I like there's a
pretty narrow band of things that you
know it's going to be one of those
things but even though there's only a
handful of things those things are so
complicated the fact that you you didn't
even smell the fumes that were creating
the problem that's terrifying because
now you have one less cue to pick up on
so this actually happened to me a while
ago maybe a year ago now
um I was having tremendous brain fog I
felt tired all the time I couldn't focus
in the way that I normally do and I was
just like what is going on like this is
so weird I could not figure it out
couldn't figure it out and I honestly
was like am I just overwhelmed with
stress do I not like what I do anymore
like what's going on
and I thought okay if somebody came to
me and described these symptoms what
advice would I give them and I'm like
it's something you're eating yeah and
I'm like but I'm not I know my diet is
so clean there's nothing I'm eating
that's problematic and I'm like I would
still tell the person whatever you're
eating a lot of stop eating it and see
what happens I happen to be eating a lot
of pecans at the time so I thought well
pecans are the only thing I'm eating a
lot of let me just cut them out and see
what happens 72 hours later I felt
perfect yeah I was like what the [ __ ]
cons like how is this possible yeah it
seemed so unreal because I thought of
pecans I mean they were raw pecans first
of all let's start with that so it's not
even like they were
um they were being processed in some
crazy way but then I tell my sister can
you believe this is the weirdest thing
ever I was having all this brain fog I
stopped eating pecans and now I'm fine
she's like oh yeah I can't eat pecans
either if I eat them I get migraines and
I was like what I'm like it that was so
weird to me yeah and to one to think
that it is a knowable thing because my
sister has the exact same it didn't
manifest exactly in the same way but
that it was a problem for her that she
could track back as well but that it was
so delayed and this is my real point
with health and what you eat and what
you're exposed to is so terrifying it's
like steering a boat when you're in a
car the second you turn the car moves in
a boat you turn the wheel and three
seconds later it starts to move and so
it's very difficult to steer if you're
inexperienced the same is true of Health
you may not like it took 72 hours for
the symptoms to go away so if I had
stopped eating for 24 hours and I
thought nope no change and started
eating it why do you leave them out if
it doesn't make a difference and started
eating them again yeah then it goes on
forever and now I can't make the
connection you know the exact same thing
happened to me by the way and often when
it comes to Foods it's not always the
food it's the processing even even
something like a pecan where you think
it's not processed there's something
there and let me give an example there's
a drink that I like I like carbonated
drinks bro right me too yeah now I
figured how do I get something with some
flavor that doesn't have any sugar in it
so I found one with stevia and according
to Ben Greenfield no problem right so I
started drinking it uh and I I had minor
headaches that week the next week I
started turning into brain fog right and
this is what I said I'm doing something
that's causing an inflammatory response
what is it and I didn't lean on this
because it seemed so clean and healthy I
had this pre you know I just thought it
was great but anyways I read carefully
so there's the water there's Stevia but
there was a natural flavor right natural
means it's from a plant or an animal
which seemingly should be fine right
what does it take to derive a natural
flavor and put it into your food between
50 to 100 chemicals whoa yeah the
average is 70. 70 chemicals so take a
natural flavor get it into the material
that it needs to where it actually is
usable in food but none of that is
listed as an ingredient because it's not
an ingredient it's a processing chemical
it's not on the package you don't get to
see the 70 things you just ingested
right right so I stopped drinking it
like yourself after the third day
symptoms were gone because the
inflammation Cycle takes some time to
recover you're inflamed right that would
have led to mood issues
neurological inflammation that would
have led to arterial inflammation just
like my friend that had the golf problem
I don't have the best quality arterial
lining right so
it just depends how much inflammation
are you getting from what sources you
got to cut it all out and you can feel
amazing
yeah man this is uh aging is a big deal
aesthetically but also from a
performance standpoint and getting that
stuff right how much of this can we move
backwards so your arterial flexibility
you actually move backwards it got more
elastic again which is phenomenal so
I'll just throw out a PSA you are what
you eat yes and you are what you ate ate
so if your cows are eating Skittles yeah
which I can't believe is a real thing
yeah uh then you're eating meat yeah
where the Skittles at a minimum would be
stored in the fat but even just like
from uh you're turning over I think
every cell in the body turns over what
every 12 years maximum and most of them
are turning over a lot faster than that
so if you're ingesting something then
whatever those cells are made of you're
going to be intaking
and so you can move your things like
arterial flexibility back but can you
with the telomeres I'm much more
familiar with the Horvath clock and like
I don't know does that matter as much
because arterial flexibility the things
we're looking at that's looking at
epigenetic expression right so what does
that mean your genome is here's the
instructions you have here's what your
cells are being told what to do your
epigenetic expression is now based on
your environment nutrition lifestyle
factors the load you put on this DNA
some of those Gene instructions may be
sped up or slowed down you eat a
blueberry it does something to your
genes a specific Gene perhaps right
women know that if you use curcumin and
turmeric it slows certain or dim for
example it helps them with their hormone
imbalances that was dim it's a
supplement that is in any female
menopause or hormone estrogen dominance
supplement so if I have your DNA I can
tell you exactly how your hormone
Cascade looks meaning like yourself just
by looking at you Androgen dominant a
lot of testosterone not a lot of
estrogen and good clean androgens not
the toxic DHT you don't clear it you
also don't you know you don't convert
like I said earlier right so it's clear
from your phenotype your manifestation
of the genes so all of a sudden you can
be very clear about that stuff and then
if somebody like yourself is Android and
dominant
they can start to pick at that and say
well now what problems does that cause
it's a benefit to you you're going to
live a little longer you're going to
have a little more Vitality you're not
going to age as fast right but it could
lead to the truth is hitting your career
goals is not easy you have to be willing
to go the extra mile to stand out and do
hard things better than anybody else but
there are 10 steps I want to take you
through that will 100x your efficiency
so you can crush your goals and get back
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free by clicking the link in today's
description alright my friend back to
today's episode
prostate issues right it could lead to
if you were to God forbid against
something like covid you might get a
little more sick than other people whoa
myocarditis right why is it that so many
young men are that's the outcome of
injecting something because of what's
happening with their testosterone level
then why not every young man only some
right because their hormone paths are
different the genes that are instructing
what they do with their hormones are
different
so if you are in that bucket where you
net out like yourself a lot of clean
androgens myocarditis is a real risk
right where it isn't for some other
people and that's why I'm saying that
the very first thing I said is
personalization any question you ask the
answer isn't the same for all of us the
same thing that could be highly
beneficial for somebody first thing we
talked about cardiovascular activity
right let's get into that
your oxidative pathway what happens when
you're running you're taking in more
oxygen
all the cells in your body take in
oxygen and nutrition to create energy
right and in that process of using
oxygen to make energy you also create an
oxidant and that oxidant is a free
radical it's toxic it causes
inflammation
your cells is a gene called sod2 which
is meant to clear this from the cell so
it's meant to go find it get rid of it
put it into the blood and then your
detox Pathways catch it grab it send it
to the liver and then you're done if you
don't do that well
then it's kind of like having a
fireplace with no chimney
and the soot is just
piling up and you're running on the
treadmill and that oxidation is choking
yourself and aging it faster creating
that inflammatory state that you
shouldn't have because you're doing
something that is misaligned to your
genetic capacity right if you also don't
detoxify well it's also now causing
inflammation in other parts of your body
so that thing could be the root cause of
your cholesterolemia because again an
inflammatory insult to bad Hardware
right or that thing if you deal with
oxidation really well
then you do get the cardiovascular
benefit because your cells are not
choking in oxidation
and it's going to add 10 years to your
life
right so the habit misaligned to your
genome equals problems a habit of line
to your genome equals life extension
Jesus man so
we get so much advice
and from diet eat like this I remember
as a kid my dad was very overweight and
the doctor was like if you don't change
your diet you're going to die and their
advice though was to basically go high
carb low fat yeah whoops so not great
advice the good news is that my dad is
hyper disciplined so he just restricted
the life out of his calories and ended
up losing a lot of weight awesome
um but
that is just thankfully in fact I'd be
so curious to see if you can actually
see willpower in the the genetics
because man I have me some willpower
yeah like that is for sure yeah and I
think my dad probably does as well
watching him like go
because there's the book
um
what's it called oh God it's something
about live or die something like that I
forget and it it tracks people and can
they make the very simple decisions that
they need to elongate their life and 95
of people if all they have to do is take
a single pill once a day for the rest of
their life to elongate their life by
like five or ten years they don't do it
yeah and I'm scandalized by that yeah
but so I said this is this is my
favorite part about what we do and I'm
not a scientist I'm not a clinician I
was sick and I found a solution and I
built a company around it right because
I just felt everybody needed it
um the thing that I personally have
focused on building that I found was the
most broken in genomic interpretation
was the brain and mood and behavior most
people didn't believe that there was an
answer so that that belief that 99
people won't take the pill
it said 99 of people were given the
prescription in a way that doesn't align
to their thinking they will all take the
pill if you understand how they think
now you're in my zone yeah how is that
possible so take me for example
the dopamine pathway which you're
familiar with pleasure and reward right
that chemical allows you to feel these
two things we understand biologically
how that happens and we understand what
Gene instructs each step so first of all
uh sensorial type activity happens in
three phases the anticipation you know
what's coming you smell the tasty PDS of
the steps of dopamine these are the
steps of dopamine and most other sort of
feelings right anticipation of the
feeling you know it's about to happen as
long or short as it takes then it
happens you're in the moment and then
you have to clear it you have to come
back to normal so that's clear the
neurochemistry the actual dopamine from
this yes so the way I anticipate and
bind experience my ability to bind my
sensors the actual receptors are very
sparse so this Gene called drd2 which
determines the density of those
receptors and I'm slim to none okay I
want to walk people through this this is
important it's the same with insulin and
Insulin yeah exactly yes so you have a
cell yeah and I I'm going to describe it
what I think is true but jump in if I'm
inaccurate so you have a cell on the out
outside of the cell are receptors
basically I imagine them as like little
grabbing hands or locks and you've got
dopamine floating around as a thing to
be grabbed or Keys have whatever analogy
you prefer and they if you have a lot of
receptors there's a lot of grabbing
hands boom they grab the dopamine
there's a lot of locks for that key to
unlock if you have very few receptors
which it sounds like you do even if
there's a lot of dopamine present in the
system there's just not a lot of things
trying to grab the dopamine and so you
could take your blood and be like word
you've got all the dopamine dopamine is
not your problem exactly yeah but in
reality
is the problem but the third part so
presence of dopamine ability to bind
dopamine or any chemical and then
clearing it out of the system have it
okay those are the three important now I
have the minimal ability to bind so when
I experience or feel it's way down here
right the maos and other gen Gene that
breaks it down and I have the fastest
possible Mao comp produces A protein
that helps now clear that broken upper
tablet I have the fastest possible pump
so when the way I experience the world
is pleasure and reward our way down here
and it lasts that long it's done before
it started
so I have three potential outcomes and
this is exactly why I said the reason
why they don't take the pill is that the
prescription is misaligned to their
thinking
for me if I'm not doing king or they are
experienced their perspective perception
the way they're perceiving what's
happening right so the way I perceive
the world sucks
I'm depressed right I don't get to enjoy
and I don't feel a reward for real for
real you feel that most days or you
found a way to combat it if I don't go
down the path of reward or pleasure I
could very EAS very easily become
addicted because when I do feel that
pleasure hit from anything could be good
or bad I need more and I need more and
I'll structure my day around it and it
becomes the core Hub again of all these
problems if I go down the pleasure path
dopamine also Powers reward I might go
down that path and then also and they
become entrepreneurial and I take big
risks and I do stupid things that nobody
else will do like walking away from my
startup company and building a genomics
company which I have no business doing
right so that's where by the way I've
experienced all three
and why is that important because the
outcome here's your biological pathway
here's the genes and a structure I can
predict your behavior and your possible
outcomes the context you're in will now
determine the net result
if I'm in a context where there's no
pleasure or a word I'm going to be
depressed
if I'm in a context where I'm seeking
pleasure
I'm going to get addicted if I am
struggling and I need to fight what we
call Warrior genetics which is what I'm
made up of I can get deeper into that I
will strive and I will Thrive and I'll
accomplish great things right because of
my need for more reward whatever I did
yesterday isn't good enough today
that's that's true for depression
addiction ADHD all these things that
we've labeled as problems
and why are they so hard to measure and
treat because they're very different for
different people so if you have the same
pathway like myself the opposite picture
of the flip opposite the maximum binding
of dopamine in a very slow clearance
that person has such an easy time
experience pleasuring a war that they
become call it flaky they're just not
interested they're not motivated because
everything's already good enough walk
out of a meeting with 10 action items
yeah great they don't even start eight
of them because they already feel the
sensor reward just by talking about it
but the two that they really enjoy
because the clearance takes them long
they end up binging
right the thing that gives them that
elevated sense they get stuck in it and
they binge so these are the people that
are like subject matter experts me
I want every opportunity I can't say no
right and I want to do this and I want
to do this and I want to do it amazing
they're like all this sucks no I don't
care about your Netflix TV show but the
one that I like I'm watching six
episodes
right so the same pathway creating two
very different results and we can talk
about all the different Pathways and
it's the same for all of them
it's really interesting but the if I had
to guess and this is absolutely a guess
I have a tremendous ability to feel the
dopamine so I get excited man I am very
easy to excite yeah but I have a feeling
that my dopamine clears fast yeah so I'm
always on to the next yeah and I have
said and I mean this without I'm not
trying to be funny
my need for uh the next thing the next
thing the next thing borders on
pathological yeah and I'll be very
curious to see how that manifests so we
you're probably right and I'll tell you
that part of the work that I've
personally done again I'm not a
clinician so I don't treat patients but
I've interviewed hundreds of people
about their mood and behavior their
brain very purposely because first of
all I love it second because I came in
with a different perspective that wasn't
the genetic Norm right so I I
interviewed I would say over 100
millionaires right and maybe a couple
well I would say about seven to twelve
billionaires right to understand how
they think and it just happened to be
that we're part of part of our research
to understand mood and behavior why did
they do what they did right I also I
also interviewed nurses and firefighters
to understand why are they so reliable
and dependent in these rocks that we can
lean on right to understand their neural
behavior and what I learned is somebody
like yourself who's Mission driven right
but is able to build is exactly what
you're describing very easy to feel but
it doesn't last long enough
which is why you need it and you need it
and you need it but when you do it right
you're in it you have enough pleasure
it's not the pathological thing that
you're hanging on to that little rope is
the ability to maintain it
the what I do is I take a little bit too
much risk so I'm either going to build a
billion dollar company or Crash and Burn
right what's happening day to day isn't
good enough
so and this is what we learned and this
was consistent when I when I interviewed
a hedge fund manager
exactly like you uh except they also had
a very strong ability to say no
right their their job was to not lose
more important than to make right the
average for a hedge fund Banner is 50 50
anyway it's like costing it tossing a
coin right so it's how do I not lose as
opposed to how I make so they're very
risk adverse the guy that hired the
hedge fund manager the billionaire that
owns the company does not think that way
but he knows he needs these people
around him to not lose and not screw up
and we learn that people kind of fall in
place when there's a risk averse guy is
dopamine profile look like so it's it's
it's very similar to what you're
describing where the ability to feel
that is high uh but they don't they
clear it a little quicker so they can
move on and make others and multitask
multi-prioritized the key thing that
they do differently however is that
their ability to deal with the what we
call Brain Drive neurotropic Factor bdnf
so bdnf determines neuroplasticity the
ability to develop neural Pathways they
don't do that well
right so they're not good at wearing
multiple hats they're not good at
looking they're hyper focused in subject
matter experts they do this thing with
tunnel vision
right they also their serotonin pathways
are off and when we talk about serotonin
we usually look at it as depression and
mood
uh but when you look at it more
functionally this is what we learned by
actually sitting in front of people and
interview them by the way we interviewed
7 000 people so it's the largest
clinical in-person genomic study in the
world and this is the gap between here's
genetics 80 chance Alzheimer's versus
how did I not get it we learned that by
actually meeting people so in that we
learned that these people once again
their serotonin pathway is off the
actual receptor was a little short and
they're disregulated for their ability
to deal with mood but serotonin has a
key uh attribute that people don't use
it for which is prioritizing stimulus
what does that mean we're sitting here
we're focused and we're talking some
people can't do that they're noticing
the camera they're noticing the lights
there's a flicker there's a sound
there's a smell there's a whatever right
these people have that problem meaning
that every little detail and Nuance
bothers them so in their behavior they
might seem irritable
they might seem easy to frustrate easy
to distract also but when they're
reviewing things every little T and I
that needs to be crossed and dotted they
see and when they come back to the table
to speak to whoever they come back with
this deep highly analytical report that
nobody else could actually do right and
but it causes other problems they can't
sleep at night
why can't they sleep at night because in
your second half of your sleep cycle
first half good deep sleep typically
these people don't have a problem with
that in the second half at some point
your body is supposed to wake up it
knows that I'm going to be awake at some
point
just like melatonin puts you to sleep
serotonin wakes you up so you make it in
your sleep sunlight comes through the
window pierces through your eyelid and
you're supposed to start binding
serotonin and be awake
so that stimulation because they can't
prioritize stimulus they don't know if
the temperature off or the weird noise
or the you know hubby's pulling on the
blanket all of that sensorial problem
triggers the serotonin binding serotonin
binding serotonin because their body
doesn't know what to focus on and then
they can't sleep in the second half of
their night
right so this functional you know
approach to their specific problem as
opposed to take a pill which once again
may not actually solve their problem
right so we learned all of this stuff by
sitting in front of people interviewing
them and just continues to blow my mind
every day are we slaves to our genetics
so no not at all and this is this is the
misconception that your genes are your
destiny
right they are your destiny if you don't
understand them and you're doing
everything wrong right and for the most
part we aren't designed for our current
reality that is true for most people
what does that mean give me a quick
thumbnail sketch of current reality
current reality is you go to work and
there's chemicals that paint to the wall
there's chemicals that cleaned your
carpet you're working on a desk that was
just cleaned by the cleaning guy you
received mail and you're talking
touching a package with pollution all
over it right are you designed to cope
with all that you're going for a quick
bite at lunch and something that was
wrapped in plastic you're ingesting
microplastics are you designed for that
you didn't sleep enough and you're
stressed for eight hours straight and
producing cortisol is that what your
ancestors did right you're not outside
getting vitamin D which by the way of
the 30 000 some odd genes in your body
10 of that 10 of your genes require
vitamin D to function
yeah so ten percent of your human
biochemistry is dependent on this one
micronutrient
right and you're indoors for 10 hours 12
hours and then you go home and you're
indoors again right so we're not doing
what we're designed for not in our fault
we don't know what we know I can do
whatever I want and when I break myself
the doctor will fix me that's what we
know right we don't ask or don't even
believe that it's possible to not get
there to not be sick in the first place
quick derail on the vitamin D sure
so I I get vitamin D as a matter of
religion yeah
because I read something
how true this is I'm not entirely sure
but it sounds like where you're going
that this will be pretty accurate that
if you get skin cancer
you are more likely to survive skin
cancer if you get a sunburn than you are
if you get no sun let me say that again
if you get skin cancer you're more
likely to survive if you get a sunburn
than if you don't get any more sun
that's insane yeah I was like I'm sorry
what so that's when I was like all right
I gotta get son I believe that vitamin D
has been rebranded vitamin D
it's actually a hormone I believe it's
been rebranded because every everybody
had enough there'd be a much lesser
expenditure in healthcare
right why call it vitamin D because they
want people to supplement you're take
you're taking away its value by what you
named it I see it's a sheep in it it's
truly a hormone got it it's like calling
testosterone vitamin T and putting it on
the shelf right but understanding how
important testosterone is That's What
vitamin D is it's truly a hormone that's
why so much is dependent and it's not
just it's and it's not a direct
correlate a vitamin D prevents or stops
cancer if 10 of your biochemistry is
dependent on this thing and you don't
have it everything's out of whack why do
you feel off in the winter you know why
do women get osteoporosis problems and
some don't
what are all these things that are
dependent on this one again Hub going
back to that central theme of find the
Hub the thing that's broken in your
biochemistry fuel that properly and all
the spokes go away
right yeah man so vitamin D I think is
incredibly important but I have a
conflicted relationship with the sun's
potential effects on aging and wrinkles
and is it just yep sorry the sun you
need it but the sun is going to age your
skin for sure so then understanding how
you do that right we don't all ages the
same way we don't all have the same
negative outcome from too much sun did
your ancestors come from an equatorial
climate no then you probably aren't
meant to be in the sun all day and if we
look at your vitamin D profile I can
predict and we'll look at it when you
need your genome back vitamin D is the
only micronutrient that has a multi-step
metabolism process a vitamin C vitamin A
there's one gene that takes it puts it
in your blood that's it simple because
our ancestors did different things and
had different exposure you know your
ancestry might be a little bit Northern
a little less sunlight more clouds right
yeah and so what they probably did had a
really good ability to Step One draw D2
from the Sun and convert it into D3
that's step one that's one gene then
once it's in the blood you need to
transport it to the cell where it's
actually used that's a second Gene
then once it's at the cell you need to
bind it like you said those guys that
are catching the stuff and connect to
your cell that's another Gene so this
pathway you'll find that there's a high
variability between people who are more
equatorial that don't do this process so
efficiently right and then people that
means they need more they need more
or they need multiple they may need
multiple doses that's where they may get
it wrong you mean multiple doses meaning
that okay I do a good job of bringing it
into the system but I don't transfer to
the cell and I don't bind it that means
if I take my couple thousand IU in the
morning I've only used 500 of it aren't
you super suspect though of
supplementing the sun like I don't I'm
ignorant nobody should listen to me but
here's my big concern that there's way
more going on when Sun hits your skin
than we think and if you're just trying
to supplement the isolated D3
you there's almost certainly things
you're not doing for instance correct me
if I'm wrong but I think the sun
penetrates far enough to get into the
bone that's crazy yeah it that sun
exposure again what did your ancestors
do they got out they started working in
the morning right they're outside
working so taking a vitamin b supplement
is a acute Band-Aid response to living
in New York inside in the winter
your walking Outdoors is not going to
help you right because you're not
producing vitamin D you're not getting
enough sun it's like too low or
something it's it's just not enough
right in the winter there just isn't
enough in certain areas so you have to
supplement that's what supplement means
add more right so but if you are in
Phoenix or here in La you know you're
good you probably don't need as much if
you go outside that's if you go outside
I just live in L.A I lived in L.A for a
long time but I was afraid of the Sun so
I never went out I'm sure I was wildly
yeah and there's so much that's
triggered I suppose I should finish that
yeah
and it's not just um so it's also your
sleep right your eyes seeing sunlight in
the morning triggers the start of your
clock
how many people can't sleep at night
because they don't start their day
properly
the Circadian rhythm there's genes that
direct that there's literally a gene
called clock
that Regulators are being called clock
yeah and it literally regulates your
clock your internal clock cleverly name
yeah so if you have the bad version of
it and you're not starting your day the
right way your body can't cope with
whatever you're doing right you're on
Netflix till midnight blue light we talk
about there's some people that say well
my laptop doesn't bother me I can be on
my phone until I knock out and I have no
problem some people need to shut it off
two hours before so starting your day
the way your ancestor started which is
out in the sun your eyes getting that
dose of sun like actual sunlight will
turn your circadian rhythm clock on so
that your body knows what time to sleep
right just simple things like that yeah
going back to your idea of ancestral
stuff and not thinking about your
grandparents because we're already now
that's what a hundred years ago versus
the 200 000 I've heard you say 200 000
and 250 000. that we've basically been
modern humans yeah that's the range
right uh and different people will say
different things but something happened
around that time where we became who we
are so our brain changed right we done
we developed emotion we developed
complicated speaking skills uh our
bodies changed and we basically whatever
you believe about where we came from uh
whether it's the religious belief or the
scientific belief we became who we are
yeah right humans don't existed uh we
did not change and we still haven't
changed so if you look at the Genome of
that 200 to 250 000 year old person it's
exactly the same as it is today if you
are a Ferrari right here and you've
designed to be a Ferrari and you race a
track for 200 000 years and all of a
sudden every Ferrari is going off-road
they're all going to break all of them
because they were not designed for that
and that's what we're doing to ourselves
we're all that fish in the Fishbowl
we're industrialization you know
processing uh and it's it's so much more
worse for women you wonder why there's
the prevalence of why is it that you
know 80 of the Alzheimer's cases are in
women eighty percent of the research
dollars are spent on men it's more than
that actually but the cases are in women
because they also have to deal with a
cofactor of estrogen toxicity which we
don't as much some of us do but most of
us don't which is another internal
source of inflammation
and these same chemicals that I'm
talking about that cause inflammation
also mimic hormones as they enter your
body so imagine you're a woman that in
your hormone Cascade
we can determine progesterone converts a
testosterone converts to estrogen and
there's nuances in how you do that men