Jamie Metzl: Lab Leak Theory | Lex Fridman Podcast #247
K78jqx9fx2I • 2021-12-08
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Kind: captions Language: en the following is the conversation with Jamie Metzel author specializing in topics of genetic engineering biotechnology and geopolitics in the past two years he has been outspoken about the need to investigate and keep an open mind about the origins of covid-19 in particular he has been keeping an extensive up-to-date collection of circumstantial evidence in support of what is colloquially known as lab leak hypothesis that covid-19 leaked in 2019 from the Wuhan Institute of virology in part I wanted to explore the idea in response to the thoughtful criticism to parts of the Francis Collins episode I'll have more and more difficult conversations like this with people from all walks of life and with all kinds of ideas I promise to do my best to keep an open mind and yet to ask hard questions while together searching for the beautiful and the inspiring in the mind of the other person it's a hard line to walk gracefully especially for someone like me who's a bit of an awkward introvert with barely the grasp of the English language or any language except maybe Python and C plus plus but I hope you stick around be patient and empathetic and maybe learn something new together with me this is a lux Friedman podcast to support it please check out our sponsors in the description and now here's my conversation with Jamie Metzel what is the probability in your mind that covid-19 leaked from a lab in your write-up I believe you said 85 percent I know it's just a percentage we can't really be exact with these kinds of things but it gives us a sense where your mind is where your intuition is so as it stands today what would you say is that probability I would stand by what I've been saying since really the middle of last year it's more likely and not in my opinion that the pandemic stems from an accidental lab incident in Wuhan is it 90 is it 65 percent I mean that's kind of arbitrary but when I stack up all of the available evidence and all of it on both sides is circumstantial it weighs very significantly toward a lab incident origin so before we dive into the specifics at a high level what uh types of evidence what intuition what ideas are leading you to uh to have that kind of estimate is it possible to kind of condense when you when you look at the wall of evidence before you where's your Source the the strongest source of your intuition yeah and I would have to say it's just logic and deductive reasoning so before I make the case for why I think it's most likely a lab incident origin let's just say why it could be and still could be what we natural origin all of this is a natural origin in the sense that it's a bat virus backbone horseshoe bat virus backbone okay I'm Gonna Keep pausing you yeah to find stuff so maybe it's useful to say what do we mean by lab leak what do we mean by natural origin what do we mean by virus backbone okay great questions um so viruses come from somewhere viruses have been around for 3.5 billion years and we they've been around for such a long time because they are adaptive and they're growing and they're always changing and they're morphing and that's why viruses are I mean they've been very successful and we are are victims sometimes we're beneficiaries we have viral DNA has morphed into our our genomes but now certainly in the case of covid-19 we are victims of the success of viruses and so when we talk about a backbone so the SARS cov2 virus um has a it has a history and these viruses don't come out of whole cloth there are viruses that that morph and so we know that at some period maybe 20 years ago or whatever um the the the virus that is SARS cov2 existed in horseshoe bats it was a horseshoe bat virus and it evolved somewhere and there are some people who say there's no evidence of this but it's a plausible Theory based on how things have happened in the past maybe that virus jumped from the horseshoe bat through some intermediate species so it's like let's say there's a bat and then it infects some other animal let's say it's a pig or a raccoon dog or a civet cat they're all Pangolin they're all sorts of animals that have been considered and then that virus adapts into that new host and it changes and grows and then according to the quote-unquote Natural Origins hypothesis it jumps from that animal into humans and so what you could imagine and some of the people who are making the case all of the people actually who are making the case for a natural origin of the virus what they're saying is it went from bat to some intermediate species and then from that intermediate species most likely there's some people who say it went directly Back To Human but through some intermediate species and then humans interacted with that species and then it jumped from that whatever it is to to humans and that's a very plausible Theory it's just that there's no evidence for it and the nature of the interaction is do most people kind of suggest that the like What markets so the interaction with the humans the animal is in the form of it's either a live animal that's being sold to be eaten or uh recently live animal but newly dead animal being sold that's certainly one very possible possibility a possible possibility I don't know if that's a word but the people who believe in the wet Market origin that's what they're saying so they had one of these animals they were cutting it up let's say in a market and maybe some of the blood got into somebody maybe had a cut on their hand or maybe it was aerosolized and so somebody breathed it and then that virus found this new host and that was the the human host but you could also have that happen in let's say a farm so it's happened in the past that let's say that there are farms and because of human encroachment into Wild Spaces we're pushing our our farms and our Animal Farms further and further into what used to be the the just natural habitats and so it's happened in the past for example that there were bats roosting over pig pens and the bat droppings went into the pig pens the viruses in those droppings infected the pigs and then the pigs infected the the humans and and that's why it's a plausible Theory it's just that there's basically no evidence for it if it was the case that SARS cov2 comes from this type of interaction um as in most of the at least recent past outbreaks we'd see evidence of that viruses are messy they're constantly undergoing darwinian Evolution and they're changing and it's not that they're just ready for Prime Time ready to infect humans on day one normally you can trace the viral Evolution prior to the time when it infects humans but for SARS cov2 it just showed up on the scene ready to infect humans and there's no history that anybody has found so far of that kind of a viral Evolution with the first SARS you could track it by the The genome sequencing that it was experimenting and uh SARS cov2 was very very stable and meaning it had already adapted to humans by the time it interacted with us fully adapted so with SARS there's a rapid Evolution when it like first kind of hooks onto a human yeah because it's trying like a virus its goal is to survive and replicate yeah no it's true it's like oh we're going to try this oh that didn't work we'll try exactly like it like like a startup and so we don't we don't see that and so there are some people who say why well one hypothesis is are you have a totally isolated group of humans maybe in in southern China which is more than a thousand miles away from uh from Wuhan and maybe they're doing their animal farming um right next to these uh where these areas where there are these horseshoe bats and maybe in this totally isolated place that no one's ever heard of they're not connected to any other place one person gets infected and it doesn't spread to anybody else because they're so isolated they're like I don't know I mean I can't even imagine that this is is the case then somebody gets in a car and drives all night more than A Thousand Miles through crappy roads to get to Wuhan doesn't stop for anything doesn't infect anybody on the way no one else in that person's village infects anyone and then that person goes straight to the the juanan seafood market according to this in my mind not very credible Theory and then unloads his stuff and everybody gets infected and they're only delivering those animals to the Wuhan Market which doesn't even sell very many of these kinds of animals that are likely intermediate species and not anywhere else so that's it's a little bit of a straw man um but on top of that the Chinese have sequenced more than 80 000 animal samples and there's no evidence of this type of a viral Evolution that we would otherwise expect Let's uh try to at this moment steal man the argument for the natural origin of the virus so just uh to clarify so Wuhan is actually despite what it might sound like to people is a pretty big city there's a lot of people that live in it 11 million so not only is there the Wuhan Institute of virology there's other centers that do work on viruses yes but there's also a giant number of markets and everything we're talking about here is pretty close together so when I kind of look at the geography of this I think when you zoom out it's all Wuhan but when you zoom in there's just a lot of interesting dynamics that could be happening and where the cases are popping up and what's being reported all that kind of stuff so I think the people that argue for the natural origin and there's a few recent papers that come out arguing this it's kind of fascinating to watch this whole thing but I think what they're arguing is that there's this Hunan Market that's one of the major markets uh the wet markets in Wuhan that uh there's a bunch of cases that were reported from there so if I look at for example the Michael Warby perspective the hero in science he argues he wrote this a few days ago the the predominance of early covet cases linked to Hunan market and this can't be dismissed as ascertainment bias which I think is what people argue that you're just kind of focusing on this region because a lot of cases came but there could be a huge number of other cases so people who argue against this say that this is a later stage already right um so he says no he says this is this is the epicenter and uh this is a clear uh evidence that uh circumstantial evidence but evidence nevertheless that this is where the jump happened to humans the big explosion maybe not k0 I don't know if he argues that but with the early cases so what do you make of this whole idea Can you steal man it yeah before yeah and my goal here isn't to attack people on on the other side and and if my feeling is if there is evidence that's presented um that that should change my view I I hope that I'll be open-minded enough to change my view and certainly Michael Warby is a thoughtful person a respectful a respected scientist and and I think this work is is contributive work but I just don't think um uh that it it it that it's as significant as has been reported in in the press and so what his argument is is that there is an early cluster in December of 2019 around the the Juan on seafood market and even though he himself argues that the original break through case the original case the index case where the first person infected happened earlier happened in October or November so not in December his argument is well what are the odds that you would have this number this cluster of cases in the huanan seafood market and if the origin happened someplace else wouldn't you expect other other clusters and it's not an entirely implausible argument but there are reasons why I think it's uh that it's this is not nearly as determinative as has been reported and I certainly had a lot of I and others had tweeted a lot about this and that is first uh the the people who were infected in this cluster it's not the earliest known uh virus of the SARS cov2 it began mutating so this is it's not the original SARS cov2 there so you it had to have happened someplace else too the people who were infected in the market um weren't infected in the part of the market where they had these kinds of animals that are considered to be candidates um for as an intermari intermediary species and third there was a bias actually I'll have four things uh third there was a bias in the early assessment in China of what what they were looking for they were asked did you have exposure to the market because I think in the early days when people were figuring things out that was one of the questions that uh that was asked and fourth and probably most significantly we have so little information about those early cases in China and that's really unfortunate and we'll talk about this later because the Chinese government is preventing access to all of that information which they have which could easily help us get to the bottom at least know a ton more about how this pandemic started and so this is it it's like grasping at straws in the dark with gloves on that's right but to steal man the argument we have this evidence from this market and yes the Chinese government has turned off the lights essentially so we have very little data to work with but this is the data we have so who's to say that this data doesn't represent a much bigger data set that a lot of people got infected at this Market where it even at the parts or especially at the parts with the the meat the infected meat was being sold so that could be true and it probably is true the question is is this the source is this the place where this began or was did this just a place where it was Amplified and I certainly think that it's it's extremely likely that the Juan on seafood market was an at point of amplification and that's it's just answering a different question basically what you're saying is it's very difficult to use the market as evidence for anything because it's probably not even the starting point so it's just a good place for it to continue spreading that's certainly my view what Michael warby's argument is um is that well what are the odds of that that we're seeing this amplification at this particular in the market and if we if let's let me put this way if we had all of the information if if the Chinese government hadn't blocked access to all of this because there's blood bank information there's all sorts of information uh and based on a full and complete understanding we came to believe that all of the early cases um were at this Market I think that would be a stronger argument than what this is so far but everything leads to the fact that why is it that the Chinese government which was frankly after a slow start the gold standard of doing viral tracking for SARS one why have they apparently done so little and shared so little I think it asks it it begs a lot of questions okay so let's uh then talk about the Chinese government uh let's there's several governments right so one is the local government of Wuhan and not just the Chinese government let's talk about government uh no let's talk about human nature it just keeps zooming out yeah let's talk about planet Earth yeah no uh so there's the Wuhan local government there's the Chinese government uh led by Xi Jinping and uh there's governments in general I'm trying to empathize so my father was involved with Chernobyl I'm trying to put myself into the mind of local officials of people who are like oh shit there is there's a potential catastrophic event happening here and uh it's my ass because I we there's incompetence all over the place the human nature is such that there's incompetence all over the place and you're always trying to cover it up and so so given that context I want to lay out all the possible incompetence all the possible malevolence all the possible geopolitical tensions here all right where in your sense did the cover-up start so uh there's this suspicious uh fact it seems like that the Wuhan Institute of virology at a public database of thousands of uh sampled bad coronavirus sequences and that went offline in September 2019. what was that about so let me talk about that specific and then I'll also follow your path zooming out and it's really important is that a good start it's a great starting point yeah yeah so but there's there's a a bigger story and but let me talk about about that so the Wuhan Institute of virology um and we can go into the whole history of the Wuhan Institute of virology either now or later because I think it's it's very relevant to this story but let's focus for now on this database they had a database of 22 000 viral samples and sequence information about the viruses that they had had collected some of which the collection of some of which was supported through funding from the NIH not a huge NIH through the Eco Health Alliance it's a relatively small amount 600 000 but but not nothing um the goal of this database um was so that we could understand viral Evolution so that exactly for this kind of moment where we had an unknown virus we could say well is this like anything that we've seen before and that would help us both understand what we're facing and be better able um to to respond so this was a an act a password protected public access database in 2019 um it was in September 2019 um it became inaccessible and then the whole a few months later the entire database uh disappeared the Chinese have said is that because there were all kinds of computer attacks on this on this database but why would that happen in September 2019 before the the pandemic at least as far as as we know so so just to clarify yes it went down to September 2019 just so we'll get the year straight January 2020 is when the virus really started getting um the Press so we're talking about the December 2019 a lot of early infections happened September 2019 is when this database goes down just to clarify because you said it quickly the Chinese government said that uh their database was getting hacked right therefore the director of this part of the Wuhan Institute of virology said that oh sh oh she was the one that said it she was the one who said oh yeah boy I did not even know that part yeah okay well she's an interesting character we'll talk about her yeah uh so so the excuse is that uh that's getting cyber attacked a lot so we're gonna take it down without any further explanation which seems very suspicious and then this virus starts to emerge in October November December there's a lot of argument about that but after sorry to interrupt like but some people are saying that the first outbreak could have happened as early as September I'm not I think it's more likely it's October November but for the people who are saying that the first outbreak uh the first incident of a of a known outbreak at least to somebody happened in September they make the argument well what if that also happened in mid-september of of 2019 I'm not prepared to go there but there are some people who make that argument but I think if again if I were to put myself in the mind of officials whether it's officials within the Wuhan Institute of virology or Wuhan local officials um I think if I notice some major problem like somebody got sick some sign of uh oh shit was screwed up that's when you kind of uh do this slow there's like a Homer Simpson meme where you slowly start backing out and I would probably start um hiding stuff cya yeah yeah and then coming up with really shady excuses it's like you're in a relationship and your girlfriend wants to see your phone and you're like I'm sorry I'm just getting attacked by the Russians now that's that courteous I can't yeah I wish I wish I could I wish I could it's just I'm unsafe right now so so would it be okay if I give you my kind of macro view of the whole information space and and why I believe this has been so contentious it's it's it's so here's here's if I had to give my best guess and I underlined the word guess um of of what happened and and your background your family background with Chernobyl I think is highly relevant here so after the first SARS there was a recognition that we needed to distribute knowledge about virology and epidemiology around the world that people in China and Africa in Southeast Asia they are were the front line workers and they needed to be doing a lot of the the viral monitoring and assessment so that we could have an early alarm system um and that was why there was a lot of investment in in all of those places in building capacity and training people and helping to build institutional capacity and the Chinese government they recognized that they needed to ramp uh ramp things up and then the World Health Organization in the world Health assembly they had their their International Health regulations that were designed to create a stronger infrastructure so that was that was the goal there were a lot of Investments and and I know we'll talk later about the Wuhan Institute of virology and I won't go into that into that right now so there was all of this distributed capacity and so in the early days there's a breakout in Wuhan we don't know is it September October November uh maybe uh December is when the the local authorities start to recognize that something's happening but at some point in late 2019 uh local officials in Wuhan understand that something is up and exactly like in Chernobyl these guys exist within a hierarchical system and they are going to be rewarded if good things happen and they're going to be in big trouble if bad things happen under their watch so their initial instinct is to squash it uh it's and they my guess is they think well if we squash this information we can most likely beat back this outbreak because lots of outbreaks happen all the time including of SARS one where there was a multiple lab incidents out of out of the lab in in Beijing and so they start their cover-up on day one they they start screening social media they send nasty letters to to different doctors and others who are starting to speak up but then it becomes clear that there's a bigger issue and then the the national government of China again this is just hypothesis the national government gets involved they say all right this is getting much bigger they go in and they realize that we have a big problem on our hands they relatively quickly know that it's spreading human to human and so the right thing for them to do then is what the South African government is doing now is to say we have this outbreak we don't know everything but we know it's serious um we need help but that's not the Instinct of people in in most governments and certainly not in authoritarian governments like China and so the the national government they have a choice at that point they can do option one which is what we would hear called the right thing which is total transparency they criticize the local officials for having this cover up and they say now we're going to be totally transparent but what does that do in a system like the former Soviet Union like China now if local officials say wait a second I thought my job was to cover everything up to support this alternative reality that authoritarian systems need in order to to survive well now I'm going to be held accountable for if I'm not totally transparent like your whole system um would would collapse so the the national government they have that choice and they their only choice according to the logic of their system is to be all in on a cover-up and that's why they block the World Health Organization from sending its team to Wuhan for over three weeks they overtly Lie To The World Health Organization about human to human transmission and then they begin their cover-ups so they begin very very quickly destroying samples hiding records they start imprisoning people for uh asking basic questions soon after they establish a gag order preventing Chinese scientists from writing or saying anything about pandemic Origins without prior government approval and what that does means that there isn't a lot of data there's not nearly enough data coming out of China and so lots of responsible scientists outside of China who are data driven say well I don't have enough information to draw conclusions and then into that vacuum step a relatively small number of largely virologists but also others respected scientists and I know we'll talk about the I think Infamous Peter daisak who who say well with without any real foundation in in the evidence they say we know pretty much this comes from nature and anyone who's raising the possibility of a lab incident origin is a is a conspiracy theorist so that message um starts to to percolate and then in the United States we have Donald Trump and he's starting to get criticized for America's failure to respond prepare for and respond adequately to the outbreak and so he starts saying well I know first after praising Xi Jinping he starts saying well I know that China did it and the who did and he's kind of pointing fingers at everybody uh but uh but himself and then we have a media here that had shifted from the from the traditional model of he said she said journalism so and so said X and so and so said why and then we'll present both of those views but with Donald Trump he would make outlandish starting positions so he would say Lex is an Ax Murderer and then in the early days they would say Lex is an Ax Murderer you know Lex's friend says he's not an expert and we'd have a four-day debate is he or isn't he and then at day four someone would say why are we having this debate at all because the original point is is just is baseless and so the media just got in the habit here's what Trump said and here's why it's wrong it's very complicated to figure out what is the role of a politician what is the role of a leader in this kind of game of politics but certainly in um when there's a tragedy when there's a catastrophic event what it takes to be a leader is to see clearly through the fog and to make big bold decisions and to speak to the truth of things and even if it's unpopular truth to listen to the people to listen to all sides to the opinions to the controversial ideas and to see past all the bullshit all the political bullshit and just speak to the people speak to the world and make bold big decisions that that's probably what was needed in terms of leadership and I'm not so willing to criticize whether it's Joe Biden or Donald Trump on this I think most people cannot be great leaders but that's why when great leaders step up we write books about them yeah and I and I agree and and even though I mean I I think of myself as a progressive person I certainly was a Critic of a lot of of what uh president Trump did but on this particular case even though he may have said it in an uncouth way Donald Trump was actually in my view right I mean when he said hey let's look at this lab he said I have evidence I can't tell you I don't think he even had the evidence but his intuition that this probably comes from a lab in my view was a correct intuition and certainly I started speaking up about pandemic Origins early in 2019 and my friends my Democratic friends were brutal with me saying what are you doing you're supporting Trump in an election year and I said just because Donald Trump is saying something doesn't mean that I need to oppose it if he's if Donald Trump says something that I think is correct well I want to say it's correct just as if he says something that I don't like I'm going to speak up about that good you walk through the fire so that's a that's you laid out the story here and uh I think in many ways it's a human story it's the story of politics it's a story story of human nature but let's talk about the story of the virus and let's talk about the Wuhan Institute of virology so maybe this is a good time to try to talk about his history about its Origins about what kind of stuff it works on about biosafety levels and about Batwoman yeah so what what is the honesty of our algae when did it start yeah so it's a great question so um after SARS one which was in the early 2000s 2003 2004 um there was this effort to um to enhance as I mentioned before Global capacity including in China so the Wuhan Institute of virology had been around for decades before then but there was an agreement between the French and the Chinese governments to build a the largest bsl4 lab so biosafety level four so in these what are called high containment Labs there's level four which is the highest level and people have seen that and on TV and elsewhere where you have the the people in the different in suits and all of these protections and then there's level three which is still very serious uh and uh but not as much as as level four and then level 2 is just kind of goggles and and some gloves and maybe that and maybe a face mask much less so the French and the Chinese governments agreed that France would help build the first and and still the largest bsl4 plus some mobile bsl3 labs and they were going to do it in Wuhan and Wuhan is kind of like China's Chicago and I had actually been it's a different story I'd been in Wuhan relatively not that long before the pandemic broke out and that was why I knew that Wuhan is it's a it's not some Backwater where there are a bunch of yokels eating bats for dinner every night this is a really sophisticated wealthy highly educated and and cultured City and so I I knew that it wasn't like that even the Juan and seafood market wasn't like some of these seafood markets that they have in southern China or in Cambodia where I lived for uh for two years I mean this it was a totally open thing I'm gonna have to talk to you about some of the including the Wuhan Market just some of the wild food going on here because you've traveled that part of the world yeah well let's not get there yes let's not get distracted good as I was telling you Lex before and this is maybe an advertisement yes um is having now listened to to a number of your your podcasts when I'm doing long Ultra training runs or driving in the mountains like the really because in the beginning we have to talk about whatever it is is the topic but the really good stuff happens later so so friends if you listen to the end I you know I I have to say as I was telling you before like when I heard your long podcast with Jeron Lanier and he talked about his mother at the very end I mean it was just beautiful stuffs I don't know whether I can I can match beautiful stuff but I'm gonna I'm gonna gonna do my best you're gonna have to find out exactly stay tuned um so um so France had this agreement um that they were going to help design and help build uh this bsl4 lab in Wuhan and um it was going to be with French standards and there were going to be 50 French experts who were going to work there and supervise the the work that happened even after the Wuhan Institute of virology um uh in in the new location um uh started started operating but then when they started building it uh the the French contractors the the French overseers were increasingly appalled um that they had less and less control that the Chinese uh contractors were swapping out new things they it wasn't built up to French standards so much um that at the end when it was finally built uh the the the person who was the vice chairman of the project and a leading French industrialist named maryah refused to sign off and he said we we can't um support we have no idea um what this is whether it's safe or not and when this this lab opened remember we were supposed to have 50 French experts it had one French expert and so the the French were really disgusted and actually when the Wuhan Institute of virology in its new location opened in in 2018 um two things happened one French intelligence privately approached U.S intelligence saying we have a lot of concerns about the Wuhan Institute of virology about its safety and we don't even know who's operating there is it being used as a dual use facility and also in 2018 the U.S embassy in Beijing uh sent some people down to Wuhan to go and look at well at this laboratory and they wrote a scathing cable that Josh Rogan from The Washington Post later got his his hands on saying um this is really unsafe they're doing work on dangerous bat coronaviruses in conditions where a leak is is possible and so then you mentioned shujang Li and I'll connect that to the these virologists who I was was was talking about so there's a very credible thesis that because these pathogenic outbreaks happen in other parts of the world having Partnerships with experts in those parts in those parts of the world must be a foundation of our of our efforts we can't just bring everything home because we know that that viruses don't care about borders and boundaries and so if something happens there it's going to come here so very correctly and we have all kinds of Partnerships with experts in in these labs and shujang Lee was one of those partners and her closest relationship was with Peter dazek who's a British I think now American but the the president of a thing called Eco Health Alliance which was getting money from NIH and basically Eco Health Alliance was a pass-through organization and and you know over the years it was only about six hundred thousand dollars so almost all of her funding came from the Chinese government but there's a little bit that came from the United States and so she became their kind of leading expert and the the point of contact between the Wuhan Institute of virology and certainly Peter dazick but also uh also with with others and that was why in the earliest days of the outbreak I didn't mention that um I did mention that there were these virologists who had this fake certainty that they knew it came from nature and it didn't come from a lab and they called people like me conspiracy theorists just for raising that that possibility but when Peter dazek was organizing that effort in February of 2020 what he said is we need to Rally behind our Chinese colleagues and that the basic idea was um these International collaborations are under threat and I think it was because of that because Peter dazek's basically his his major contribution as a scientist was just tacking his name on work that xujang Lee had largely done um he was defending a lot certainly for himself and his organization so you think equal Health Alliance and Peter is less about money it's more about kind of um almost like Legacy because you're so attached to this work it's just not a human life so I I think so I mean I've been criticized for being actually I'm certainly a big critic of Peter daisig but I've been criticized by some for being too lenient I mean it's so easy to say oh somebody they're like an evil ogre and just trying to do evil and and cackling in their in their closet or whatever but I think for most of us even those of us who do terrible horrible things the story that we tell ourselves and we really believe is that we're doing the thing that we most believe in I mean I did my PhD dissertation on the Khmer Rouge in Cambodia they genuinely saw themselves as idealists they they thought well we need to make radical change to build a better future and what they described as what they felt was Radical change was was a monstrous atrocities by us so the criticism here of Peter is a uh is that uh he was uh part of an organization that was kind of um well funding an effort that was an unsafe implementation of a biosafety level for laboratory well a few things so what he thought he was doing um was and and what he thought he was doing is itself highly controversial because there's one there that in 2011 um there were I know you've talked about this with other guests but in in 2011 uh there were the first published papers on this now Infamous gain of function uh research and and basically what they did both in in different labs and certainly in the United States in in Wisconsin and in in the Netherlands was they had a bird flu virus that was that was very dangerous but not massively uh transmissive and they they had a gain a function process through what's called serial passage which means basically passing advice like natural selection but forcing natural selection by just passing a virus through a different cell cultures and then selecting for what it is that you want so relatively easily they took this deadly but not massively transmissive virus and turned it into in a lab a deadly and transmissive virus and that showed that this is really dangerous and so there were at that point there was a huge controversy there were some people like Richard ebright and Mark lipsich at Harvard who were saying that this is really dangerous we're in the the idea that we need to create monsters to study monsters I think maybe even you have said that in the past it doesn't make sense because there's an unlimited number of monsters and so what are we going to do create an unlimited number of monsters and if we do that eventually the monsters are are going to get out then there was the Peter daisik camp and he got a lot of fun funding particularly from the United States who said well and and certainly Collins and fauci were supportive of this and they thought well there's a safe way to go out into the world to collect the world's most dangerous viruses and to poke and prod them um to figure out how they might mutate how they might become more dangerous with the goal of predicting future pandemics and that certainly never happened with the goal of creating vaccines and treatments and that largely never happened but that was so Peter daisak kind of epitomized that that second second approach um and as as you've talked about in the past in 2014 there was a funding moratorium in the United States and then in 2017 that was lifted it didn't affect the funding that went to the to the Eco Health Alliance um so when this happened in in the beginning and again coming back to Peter's motivations I don't think here's the best case scenario for for Peter I'm going to give you if what I imagine he was thinking and then I'll tell you what I actually think so I think here's what he's thinking um this is most likely a natural origin outbreak it it just like SARS won and again in Peter's hypothetical mind just like SARS one this is most likely a natural outbreak we need to have an International Coalition in order to fight it if we allow these political attacks to undermine our Chinese counterparts and the Trust In This release relationships that we've built over many years we're really screwed because they have the most local knowledge of these outbreaks and even though and and this guy gets a lot more complicated even though there are basic questions that anybody would ask and that shojang Li herself did ask about the origins of this pandemic even though Peter dazak and I'll mention this describe this in a moment had secret information that we didn't have that in my mind massively increases the possibility of a lab incident origin I Peter daisak would like to guide the public conversation in the direction where I think it should go and in the in support of the kind of international collaboration that I think is necessary that's a strong positive discussion because it's true that there's a lot of political BS and a lot of uh kind of just the bickering and lies as we've talked about and so it's very convenient to say you know what let's just ignore all of these quote unquote lies and my favorite word misinformation uh and then because the way out from this serious pandemic is for us to work together so let's strengthen our Partnerships and everything else is just like noise yeah so let's and so then now I want to do my personal indictment of Peter dazek because that that's my view but I wanted to fairly because I think that that you know we all tell ourselves stories and and and I and and also when you're a science Communicator um you can't in your public Communications give every doubt that you have or every Nuance you kind of have to summarize things and so I think that he was again in this this benign interpretation trying to summarize in the way that he thought the the conversations should go here's my indictment of Peter daisak and I I I it's I feel like uh Brutus here but I I um I've not come here to praise um uh Peter daisak because um while Peter dazek was doing all of this and making all of these statements about well we pretty much know it's a natural origin and then there was this February 2020 Lancet letter where it turns out and we only knew this later that he was highly manipulative so he was recruiting all of these people he drafted the the infamous letter calling people like me uh conspiracy theorists he then wrote to people like Ralph Barrick and linfa Wang who are also very high profile virologists saying well let's not put our names on it so it doesn't look like we're doing it even though they were doing it he didn't disclose a lot of information that they had it was a strategic move so just uh in case people are not familiar Feb year 2020 Lance a letter was tldr is a lab leak hypothesis is a conspiracy theory essentially yes so like with the authority of science not saying like it's highly likely saying it's obvious duh it's uh it's natural origin everybody else is just uh is everything else is just misinformation and look there's a bunch of really smart people that sign this therefore it's true yeah not only that so there were um the people whose 27 people signed that letter and then after president Trump cut funding uh to Eco Health Alliance then he organized 77 Nobel laureates to to have a public letter criticizing that but what Peter knew then that we didn't fully know is that in March of 2018 Eco Health Alliance in partnership with the Wuhan Institute of virology and others had applied for a 14 million dollar Grant um too DARPA which is kind of like the the VC side of the Venture Capital side of the of the defense department they're kind of where they do kind of Big Ideas uh by the way as a tiny tangent I've gotten a lot of funding from DARPA they fund a lot of excellent robotics research and darp is incredible and among the things that they applied for is that we meaning Wuhan Institute of Urology is going to go and it's going to collect the most dangerous bat coronaviruses in southern China and then we as this as this group are going to genetically engineer these viruses to insert a furin cleavage site so I think when when everyone's now seen the image of the SARS cov2 virus it has these little Spike proteins these little things that that stick out which is why they call it a coronavirus within that Spike protein are these if you're on cleavage sites which basically help with the virus getting access into our cells and they're going to genetically engineer these furion cleavage sites into these bat coronaviruses the cervical viruses and then and so then a year and a half later what do we see we see a bat Coronavirus with if you're in cleavage site unlike anything that we've ever seen before in that category of SARS like coronaviruses that well yes I mean it the the DARPA very correctly didn't support that application well that's actually let's like pause on that so for a lot of people that's like the Smoking Gun yeah okay let's talk about this 2018 proposal to DARPA so I guess who's drafted the proposal is it yeah ego Health but the proposal is to do so Eco health is technically uh a U.S funded organization primarily and then the idea was to do work at Wuhan Institute of virology with yeah so it was with equal Health yes so Eco Health basically that um the one Institute of biology was going to go and they were going to collect these viruses and store them at we wanted to do but they're also going to do the actual test recording it's a really important Point according to their proposal the actual work was going to be done at the lab of Ralph Barrick at the University of North Carolina who's probably the world's leading expert on uh Corona coronaviruses and so we know that DARPA didn't fund that work um we know I think quite well that Ralph Barrack's lab in part because it was not funded by by DARPA they didn't do that specific work what we don't know is well what work was done at the Wuhan Institute of virology because wiv was part of this proposal they had access to all of the plans they had done they had their own capacity and they had already done a lot of work in genetically engine genetically altering this exact category of viruses they had created a chimeric mixed viruses they had done they had mastered pretty much all of the steps in order to achieve this thing that they applied for funding with ecohealth to do and so the question is did the Wuhan Institute of virology go through with that research anyway and in my mind there's that's a very very real possibility it would certainly explain why they're giving no information and as you know I've been a member of the World Health Organization expert advisory committee on human genome editing which Dr Tedros created in the aftermath of the announcement of the world's first crispr babies and and it was just basically the exact same story so ho John Quay Chinese scientist it was not a first-tier scientist but a perfectly adequate second-tier scientist came to the United States learned all of these capacities went back to China and said well there's a much more permissive environment I'm gonna you know be a world leader I'm going to establish both myself and China so in every scientific field we're seeing this this same thing where you kind of learn a model and then you do it in China so is it possible that the Wuhan Institute of virology with this exact game plan was doing it anyway do we possible we have no clue what work was being done at the Wuhan Institute of virology it seems extremely likely that at the Wuhan Institute of virology and this is certainly the U.S government position there was the work that was being done in Dr shu's lab but that wasn't the whole wiv we know at least a coin in the United States government that there was the Chinese military the pla was doing work there were they doing this kind of work not to create a bio weapon but in order to understand these viruses maybe to develop vaccines and treatments it seems like a very very logical possibility and then so we know that the the one instead of virology had all of the skills we know that they were part of this proposal and then you have Peter dazak who knows all of this that at that time in February of 2020 we didn't know but then he comes swinging out of the gate saying anybody who's raising this possibility of a of a lab incident origin is a conspiracy theorist I mean it really makes him look in my mind very very bad and yeah not to at least be somewhat open-minded on this because he knows all the details he knows that it's not zero percent I mean there's no way in his mind could you even argue that so it's potential because of the bias because of your focus I mean it could be the Anthony fauci masks thing whereas he knows there's some significant probability that this is happening but in order to preserve good relations with our Chinese colleagues we want to make sure we tell a certain kind of narrative so it's not really lying it's doing the best possible action at this time to help the world not that this already happened yeah but that's how like yeah I I think it's quite likely that that was the story that he was telling himself but it's that that lack of transparency in my mind is fraudulent um that the word that we were struggling to understand something that we didn't understand and that I just think that people who possess that kind of information especially when um the existence like his the entire career of Peter daisak is based on U.S taxpayers there's a debt that comes with that and that debt is honesty and transparency and for all of us and our you talked about your girlfriend checking your phone for all of us being honest and and transparent in the most difficult times is really difficult if it were easy everybody would do it and that's I just feel that that uh Peter was the opposite of transparent and then went on the offensive and then um uh had the gall of joining I know we can talk about this this um highly compromised joint study process with the the international experts and their Chinese government counterparts and used that as a way of furthering this um in my mind fraudulent narrative um that it almost certainly came from natural Origins and um and the lab origin was extremely unlikely just to stick briefly on the proposal to wrap that up because I do think in a in a kind of John Stewart way if you heard that uh a bit he yeah sort of kind of like common sense way the 2018 proposal to DARPA from equal Health Alliance and wuhanistan virology just seems like a bit of a Smoking Gun to me like that um so there's this excellent book that people should read uh called viral the search for the origin of covid-19 Matt Ridley and Alina Chan I think Alina is in MIT should probably look at the broad yeah at Broad Institute yeah yeah so she I heard her in an interview give this analogy of unicorns yeah and uh where basically somebody writes a proposal to add horns to Horses The Proposal is rejected and then a couple of years later a year later a unicorn shows up and then I was like yeah I is not your lord yeah it's like it's possible it's natural origin like we haven't detected a unicorn yet and this is the first time we've detected a unicorn or it could be this massive organization that was planning is fully equipped has like a history of being able to do this stuff as the world experts to do it has the funding has the motivation to add horns to horse
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