Kind: captions
Language: en
OIC just surprised scientists again
scientists thought OIC and other similar
drugs like wovi helped people lose
weight by working primarily in the gut
but now it's looking like the drugs'
real power could be in the brain the
active ingredient in the drugs is called
stide sagla is a molecule meant to mimic
the hormone glp1 glp1 is made in the
intestine and is released and response
to food entering the intestine it's also
made in the brain and so because of this
both your gut as well as your brain are
wired to listen to this glp1 signal
naturally produced glp1 in the gut
degrades in a few minutes in that time
it gets the pancreas to produce insulin
which helps move sugar out of the
bloodstream and into the body's cells
this is why the drugs can be hugely
beneficial for people with diabetes when
it became clear that sagla also helped
people lose weight and lots of it
scientists thought what made it so
effective was how it can work in the gut
slowing down digestion and as a result
decreasing appetite but it looks like
it's the seatide in your brain that
really helps people eat less unlike the
natural go1 stide takes days to break
down so it has time to travel into the
brain in the brain it works not only as
a hormone but also as a neurotransmitter
a kind of molecule used by the nervous
system to transmit messages throughout
your body including your brain when you
inject a drug like o that drug lasts for
many days so now it has an opportunity
to travel to the brain and also Target
some of those um you know molecules that
are there to listen to the gp1 message
um in the brain in the brain stide makes
its way to the hypothalamus a small
region that acts as the body's control
center once there it inhibits the
neurons that promote hunger and
stimulates the neurons that suppress
appetite seatide can also affect the
reward system where the brain releases
dopamine a hormone that can control
motivation pleasure and Cravings the
relationship between dopamine and
seatide is not completely understood but
one idea is that it works like this when
you see a fast food restaurant off the
side of the road your brain produces a
rush of dopamine because it thinks a
reward is coming this Rush increases the
chances that you'll pull over and get
yourself a treat but with some magati in
the brain that dopamine rush or c
is reduced making it less likely you'll
stop to get something to eat because
stide decreases Cravings this may be why
people report a reduced interest in
drinking smoking shopping and other
addictive and compulsive behaviors for
now OIC is only approved to help people
with diabetes lower their blood sugar
and wovi is only approved to help people
living with obesity or some weight
related health issues every three people
taking stem magti will be able to lose
more than 20% % of their body weight
that is very very good newer medications
like Zep bound and monjaro combine
molecules mimicking glp1 and other
hormones to help people lose weight even
more effectively there's still a lot to
learn about how exactly these drugs work
what the long-term effects might be and
what else they might treat and since
there are also glp1 receptors in parts
of the brain that control emotions
memory and even motor control that gives
us an opportunity to ask why are they
there right what are they doing and that
can give us a clue as to what this drug
could potentially be used for outside of
metabolic disease when you have a drug
that targets the brain you really have
to worry about what else is it going to
do that you're not really initially
seeing
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